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research JAK-STAT pathway-associated skin diseases: a refined functional framework for inflammatory skin diseases

June 2026 in “Frontiers in Immunology”

JAK inhibitors effectively treat inflammatory skin diseases by targeting specific cytokine signals.

research Papulopustular eruptions associated with EGFR-pathway-related targeted therapies: clinical spectrum, evidence boundaries, folliculocentric inflammation, and management considerations

July 2026 in “Frontiers in Oncology”

Papulopustular eruptions are a common dermatologic side effect of EGFR inhibitors, distinct from acne vulgaris, and are better described as therapy-associated folliculocentric inflammatory eruptions. This review examines these eruptions in the context of classical EGFR inhibitors, MEK inhibitors, and amivantamab, highlighting differences in pharmacology and clinical behavior. The mechanisms involve KLF4/IL-36γ signaling and Cutibacterium acnes-related inflammation, with potential links to hair-follicle immune dysregulation and JAK-associated signaling. Management strategies are discussed, differentiating between guideline-supported care and approaches for more severe cases.

research Age-associated inflammation inhibits epidermal stem cell function

144 citations , September 2012 in “Genes & development”

Aging causes skin stem cells to work less effectively.

research Myeloproliferative disorder associated with alopecia universalis

July 2024 in “JAAD Case Reports”

Ruxolitinib helped regrow hair in a woman with a blood disorder and complete hair loss.

Identification of Potential Key Genes and Pathways Associated with the Pashmina Fiber Initiation Using RNA-Seq and Integrated Bioinformatics Analysis

research Identification of potential key genes and pathways associated with the Pashmina fiber initiation using RNA-Seq and integrated bioinformatics analysis

36 citations , January 2021 in “Scientific Reports”

Key genes and pathways, including Wnt, NF-Kappa, and JAK-STAT, are crucial for starting Pashmina fiber growth in goats.

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community Why do we get bald from evolutionary perspective

in Chat 213 upvotes 1 year ago

Baldness is not an evolutionary disadvantage because it occurs after reproductive age. Treatments like Minoxidil and Finasteride are used for androgenetic alopecia but don't address the root cause.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 444 upvotes 5 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

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