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GlossaryKeratohyalin Granules

tiny structures in skin cells aiding keratin production

Keratohyalin granules are tiny structures found in the cells of the outer layer of the skin, specifically in the stratum granulosum. They play a crucial role in the process of keratinization, where skin cells produce keratin, a protein that helps form a protective barrier. These granules contain proteins like filaggrin, which help in the aggregation of keratin filaments, contributing to the skin's strength and resilience.

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research Existence of trichohyalin-keratohyalin hybrid granules: Co-localization of two major intermediate filament-associated proteins in non-follicular epithelia

54 citations , November 1994 in “Differentiation”

Trichohyalin is found in non-hair tissues and works with filaggrin in certain skin areas and conditions.

research Keratohyalin, Trichohyalin and Keratohyalin‐Trichohyalin Hybrid Granules: An Overview

30 citations , November 1992 in “The Journal of Dermatology”

Keratohyalin and trichohyalin proteins help form and organize skin and hair structures.

research Characterization of Mouse Profilaggrin: Evidence for Nuclear Engulfment and Translocation of the Profilaggrin B-Domain during Epidermal Differentiation

25 citations , October 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mouse profilaggrin helps in skin cell differentiation and may be involved in calcium signaling.

research Ultrastructural characteristics of trichilemmal cysts: report of two cases

2 citations , June 2001 in “Medical Electron Microscopy”

Trichilemmal cysts may form from hair follicle outer root sheath growth.

research Trichilemmoma.Cell biology of the normal human outer root sheath.

January 1995 in “Skin Cancer”

The outer root sheath in hair follicles changes during growth, with different keratinization processes in its layers.

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