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[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

26 citations , July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

research c-Kit - The Novel Receptor: Physiological Roles, Downstream Signaling and Implications in Cancer

4 citations , January 2021 in “Journal of Clinical Medical Research”

c-Kit is important for heart regeneration and cancer development.

research SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis through p53/Stem Cell Factor/C-KIT Signaling

4 citations , March 2024 in “Journal of Investigative Dermatology”

SPRY1 deficiency in skin cells causes stem cells to move to the skin surface, leading to increased pigmentation.

Casein Kinase 1 Inhibition in Keratinocytes Enhances the Migration of Melanocyte Precursors in the Hair Follicle via KitL/c-Kit Signaling Pathway

research 1339 Casein kinase 1 inhibition in keratinocytes enhances the migration of melanocyte precursors in the hair follicle via KitL/c-Kit signaling pathway

April 2023 in “Journal of Investigative Dermatology”

Blocking casein kinase 1 in skin cells can help melanocyte precursors move better, potentially helping with conditions like vitiligo or gray hair.

research Classic versus non‐classic: A survival Kit for life in the skin

2 citations , September 2009 in “Pigment Cell & Melanoma Research”

Melanocytes in different body areas have evolved to perform specific functions based on their location.

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learn Stem Cell Factor

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community Is quercetin and houttunyia cordata extract actually effective for regrowth? Just heard of it for first time reading on Cleveland Clinic website

in Research/Science 5 upvotes 2 years ago

Quercetin and houttuynia cordata extract may stimulate hair growth by enhancing cellular energy metabolism and increasing growth factor secretion. Quercetin has low oral bioavailability, and its natural tint might stain the scalp if used topically.

community I started rapidly diffuse thinning at 22. I'm 42 now and have as much hair as I did at 16. AMA

in Treatment 443 upvotes 6 years ago

Hair loss treatments like finasteride, minoxidil, ketoconazole, PRP, and microneedling helped maintain hair for 20 years. Research and try evidence-based treatments for best results.

community Found it. Sulforaphane, a phytochemical in broccoli sprouts, promotes hair growth (60% regeneration in mice) by accelerating the degradation of DHT.

110 upvotes 8 years ago

Sulforaphane, found in broccoli sprouts, promotes hair growth by degrading DHT. Users discuss its potential benefits and joke about unconventional application methods.

community Minoxidil Response Test kit in the EU?

in Minoxidil 2 upvotes 3 years ago

A user is seeking a Minoxidil Response Test kit in the EU without bundled consultations. They mention alternatives like oral minoxidil and tretinoin but prefer the test alone.

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Hair Transplant Surgeon
Dr. Kitti Kovacs, MD
Budapest, Hungary
6+ yrs

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Dr. Kitti Kovacs, MD