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GlossaryLaser Capture Microdissection

technique using a laser to isolate specific cells from tissue

Laser Capture Microdissection (LCM) is a technique used to precisely isolate specific cells or regions from a tissue sample using a laser. This allows researchers to study the genetic material, proteins, or other cellular components of the selected cells without contamination from surrounding tissues, making it particularly useful in fields like cancer research and pathology.

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research Laser Capture Microdissection Reveals Transcriptional Abnormalities in Alopecia Areata before, during, and after Active Hair Loss

16 citations , December 2015 in “Journal of Investigative Dermatology”

Alopecia areata involves persistent gene abnormalities and immune activity, even in regrown hair, suggesting a risk of relapse.

research Folliculotropic mycosis fungoides with central nervous system involvement: Demonstration of tumor clonality in intrafollicular T cells using laser capture microdissection

14 citations , February 2003 in “Journal of the American Academy of Dermatology”

Folliculotropic mycosis fungoides can affect the central nervous system in advanced stages.

research Laser capture microdissection as a method for investigating the human hair follicle microbiome reveals region-specific differences in the bacteriome profile

8 citations , March 2023 in “BMC Research Notes”

Laser-capture microdissection effectively analyzes hair follicle microbiomes, revealing region-specific bacterial differences.

research 551 Combining Laser Capture Microdissection and RNAseq Analysis to Generate a Human Anagen Hair Follicle Transcriptome Atlas

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers made a detailed map of gene activity for different parts of human hair follicles to help create targeted hair disorder treatments.

research 731 Generation of a laser capture microdissection and RNAseq-based human anagen hair follicle transcriptome atlas

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists created a detailed map of gene activity in different parts of human hair follicles.

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