The Hair Loss Encyclopedia
chemical modification on histone H3 that represses gene expression
H3K27me3 stands for trimethylation of the 27th lysine residue on histone H3, a protein around which DNA is wrapped. This specific chemical modification is associated with the repression of gene expression, meaning it can turn off certain genes. In the context of hair and alopecia, changes in H3K27me3 levels can influence the activity of genes involved in hair growth and loss.