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GlossaryHistone H3

protein that helps package DNA into chromatin

Histone H3 is a protein that helps package DNA into a compact, organized structure called chromatin within the cell nucleus. It plays a crucial role in regulating gene expression by allowing or restricting access to specific DNA regions, which can influence various biological processes, including hair growth and the development of conditions like alopecia.

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Signaling Couples Hair Follicle Stem Cell Quiescence With Reduced Histone H3 K4/K9/K27me3 for Proper Tissue Homeostasis

research Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis

31 citations , April 2016 in “Nature communications”

Certain signals are important for reducing specific chemical markers on hair follicle stem cells during rest periods, which is necessary for healthy hair growth.

research Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin

26 citations , December 2019 in “Stem Cell Reports”

Proper tissue repair in adult skin requires specific histone hypomethylation.

EZH1 and EZH2 Co-Govern Histone H3K27 Trimethylation and Are Essential for Hair Follicle Homeostasis and Wound Repair

research EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

354 citations , February 2011 in “Genes & Development”

EZH1 and EZH2 are crucial for healthy hair growth and skin repair.

The Role of Histone Demethylases in Disease

research The Role of Histone Demethylases in Disease

1 citations , January 2011 in “Springer eBooks”

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

research Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism

June 2026 in “eLife”

Red light exposure slows aging in mice by improving fat metabolism.

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