The Hair Loss Encyclopedia
enzyme crucial for hair shaft formation and maintenance
PADI3 stands for Peptidyl Arginine Deiminase, Type III, an enzyme that plays a crucial role in the formation and maintenance of hair. It modifies certain proteins in hair follicles, which is essential for proper hair shaft formation. Mutations in the PADI3 gene can lead to hair disorders such as uncombable hair syndrome, characterized by dry, frizzy hair that is resistant to being combed flat.