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GlossaryLithocholic acid

secondary bile acid produced by intestinal bacteria

Lithocholic acid (LCA) is a secondary bile acid produced in the intestines by bacterial action on primary bile acids. It plays a role in the digestion and absorption of fats and fat-soluble vitamins, but high levels of LCA can be toxic to liver cells and have been linked to certain diseases, including liver cancer.

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5 / 34 results

research 698 Effect of lithocholic acid as a ligand of vitamin D receptor on hair growth in alopecia

April 2016 in “Journal of Investigative Dermatology”

Lithocholic acid helps hair growth and regeneration in alopecia by activating vitamin D receptors.

research Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer

28 citations , January 2012 in “Biological & pharmaceutical bulletin”

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

research 700 Oncostatin M is upstream of JAK-STAT signaling during the murine hair cycle

April 2016 in “Journal of Investigative Dermatology”

Blocking Oncostatin M's role in the JAK-STAT pathway can stimulate hair growth in mice.

research 702 dsRNA induces ectopic KRT9 expression via WNT/β-catenin-mediated signaling

April 2016 in “Journal of Investigative Dermatology”

Double-stranded RNA activates a pathway that causes a skin protein to be expressed in the wrong place.

research Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism

April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”

Red light exposure can slow aging in mice by improving fat metabolism.

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community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 1 year ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

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