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Did you mean Lysyl Hydroxylase?

GlossaryLysyl Hydroxylase

enzyme modifying lysine in collagen for tissue strength

Lysyl Hydroxylase is an enzyme that plays a crucial role in the formation of collagen, a protein that provides structure and strength to connective tissues like skin, hair, and bones. It specifically modifies lysine residues in collagen, enabling the collagen fibers to form stable cross-links, which are essential for the tissue's mechanical properties. Deficiencies or mutations in this enzyme can lead to connective tissue disorders.

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Research

5 / 229 results

Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

research Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis

38 citations , June 2005 in “Matrix Biology”

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

research Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note

2 citations , October 2020 in “Journal of Pharmacology and Experimental Therapeutics”

Minoxidil does not work to inhibit lysyl hydroxylases in newborn mouse lungs.

research Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil.

63 citations , September 1987 in “Journal of Biological Chemistry”

Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.

research Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity

April 2012 in “KSBB Journal”

Minoxidil analogs can be improved for hair growth inhibition by modifying specific parts of their structure.

research Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis

6 citations , August 2024 in “Biomacromolecules”

The model helps test drugs for clubfoot fibrosis by mimicking cell environments and shows minoxidil reduces harmful collagen links.

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Community Join

5 / 13 results

community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

in Minoxidil 37 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community For those of you who are getting facial skin side effects (aging, dark circles) from minoxidil, try this, it helped me.

in Minoxidil 10 upvotes 5 years ago

The conversation provides tips to reduce facial skin side effects from Minoxidil, such as changing pillowcases, sleeping on the back, careful application, hydration, and taking breaks. One reply suggests that alcohol in Minoxidil formulations, not Minoxidil itself, may cause skin aging.

community Minoxidil actually reduces wrinkles

in Research/Science 209 upvotes 1 year ago

Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

community 137 years old and still far more hair than the average r/tressless user

in Satire 1071 upvotes 3 years ago

The post and conversation are about a user claiming to be 137 years old with a full head of hair. Specific treatments mentioned include dutasteride, RU58841, and minoxidil.

community Minoxidil and skin aging worry - which prevention methods (platelet rich plasma, microneedlig, mesotherapy, stem cells, co2, ultherapy, ...)

in Chat 4 upvotes 3 years ago

User started minoxidil, noticed forehead lines and dark circles, and asked for non-invasive skin aging prevention methods. Another user suggested using tretinoin and hyaluronic acid for long-term benefits.

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learn lysine

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