Human placental extract effectively and safely improves melasma, ulcers, and alopecia areata.
4 citations
,
December 2023 in “Frontiers in Pharmacology” Topical metformin effectively treats melasma with minimal side effects.
38 citations
,
August 2015 in “Drug Design Development and Therapy” Topical flutamide works as well as hydroquinone for melasma but needs more safety checks.
20 citations
,
April 2019 in “BioMed Research International” Treatments with sunscreen and active ingredients can reduce skin hyperpigmentation by decreasing DNA methylation.
3 citations
,
July 2024 in “Cureus” Platelet-rich plasma (PRP) shows promise for treating melasma but needs more research for confirmation.