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Mdm2 is crucial for controlling p53 to maintain healthy cells and prevent tumors.

Asiasari radix extract may be a potential treatment for melanoma because it selectively triggers cell death in melanoma cells by affecting p53 regulation.

Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.

SPRY1 deficiency in skin cells causes stem cells to move to the skin surface, leading to increased pigmentation.

The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.