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research Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease

January 2018 in “Stem cell biology and regenerative medicine”

The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.

research 1407 Mechanical force activation of TGF-β signaling controls hair follicle regression

April 2023 in “Journal of Investigative Dermatology”

Muscle around hair follicles controls hair loss by releasing a signal that causes cell death.

research JAK1 Signaling Is Involved in the Induction of Mechanical Alloknesis in Atopic Dermatitis

November 2025 in “Biomedicines”

JAK1 inhibitors can help reduce itchiness in atopic dermatitis.

research PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence

May 2025 in “Science Advances”

PIEZO1 helps keep hair follicle stem cells inactive, affecting hair growth.

WISP-1 Induced by Mechanical Stress Contributes to Fibrosis and Hypertrophy of the Ligamentum Flavum Through Hedgehog-Gli1 Signaling

research WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling

36 citations , June 2021 in “Experimental & Molecular Medicine”

Targeting Hedgehog signaling may help treat ligamentum flavum fibrosis.

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community The Real Reason For Hair Loss?

in Research/Science 6 months ago

Hair loss is linked to scalp fibrosis and tension, which result from chronic mechanical stress and androgenic signaling. Treatments include blocking androgens with finasteride, promoting hair growth with topical minoxidil, and improving scalp mobility through exercises.

community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

in Research/Science 48 upvotes 5 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community I hope ET-02 or PP405 will be released in the next 4-5 years

in Product 15 upvotes 1 year ago

PP405 is a potential hair loss treatment that may work by blocking signals that cause hair cells to stop growing, requiring daily application for effectiveness. It could serve as an alternative to minoxidil and finasteride, but it is not yet available on the market and may take several years to be released.

community Why does the same hormone grow your beard and destroy your hairline?

in Research/Science 40 upvotes 2 months ago

DHT promotes beard growth but causes scalp hair loss due to inflammation and fibrosis. Treatments like finasteride and minoxidil help with hormonal signals and blood flow but don't address underlying inflammation.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 47 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

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learn Epidermal Growth Factor

learn sh-Polypeptide-7

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