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research Localization of mechanosensitive channel TRPV4 in mouse skin

123 citations , November 2003 in “Neuroscience Letters”

TRPV4 helps sense pressure in mouse skin.

research Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis

23 citations , October 2021 in “Cell Stem Cell”

Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.

research 0932 Spatiotemporal gradient of mesenchymal stiffness controls sweat gland morphogenesis

July 2026 in “Journal of Investigative Dermatology”

Tissue stiffness affects sweat gland development by guiding cell differentiation through specific signals.

research Editors’ Picks

April 2022 in “Journal of Investigative Dermatology”

Hair shaft miniaturization leads to hair follicle stem cell loss, suggesting Piezo1 as a potential treatment target.

Single-Cell Transcriptomics Reveals Hair Growth Retardation Mediated by Aberrant Connective Tissue Sheath Contraction in Male Androgenetic Alopecia

research Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connective tissue sheath contraction in male androgenetic alopecia

February 2026 in “Nature Communications”

Inhibiting connective tissue sheath contraction may improve hair growth in male pattern baldness.

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community GT20029 Will Replace Finasteride For Hair Loss

in Research/Science 57 upvotes 2 months ago

GT20029 shows promise as a topical treatment for hair loss, potentially replacing finasteride for some due to its low systemic exposure and ability to degrade androgen receptors. However, skepticism remains about its long-term efficacy and availability, with some users expressing doubt about new treatments consistently failing to reach the market.

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