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GlossaryMelanocortin 1 Receptor

regulates melanin production, affecting hair and skin color

The Melanocortin 1 Receptor (MC1R) is a protein found on the surface of melanocytes, the cells responsible for producing melanin, the pigment that gives skin, hair, and eyes their color. Variations in the MC1R gene can influence hair color, skin tone, and susceptibility to UV radiation, and are also associated with red hair and fair skin.

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research Melanocortin Receptors in Fibroblastic Cell Types of the Skin: In Vitro and In Vivo Expression and Functional Relevance

1 citations , September 2004 in “Experimental Dermatology”

MC-1R is present in skin cells and may help reduce inflammation.

research Detection of Functionally Active Melanocortin Receptors and Evidence for an Immunoregulatory Activity of Alpha-Melanocyte-Stimulating Hormone in Human Dermal Papilla Cells

60 citations , August 2005 in “Endocrinology”

αMSH may help regulate immune responses in hair follicles and its disruption could lead to hair loss.

research Expression of Melanocortin Receptors on Cutaneous Fibroblastic Cells – Collagen and Beyond

1 citations , January 2005 in “Experimental Dermatology”

MC-1R in skin cells may influence inflammation and collagen production.

research Down-Regulation of Melanocortin Receptor Signaling Mediated by the Amino Terminus of Agouti Protein in Xenopus Melanophores

43 citations , May 1999 in “Journal of Biological Chemistry”

Agouti protein affects melanocortin receptors through competitive antagonism and receptor down-regulation.

research Non-Pigmentary Actions of Alpha-Melanocyte-Stimulating Hormone: Lessons from the Cutaneous Melanocortin System

16 citations , May 2006 in “PubMed”

Alpha-melanocyte-stimulating hormone helps manage skin inflammation and protect against UV damage.

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