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GlossaryProopiomelanocortin

precursor protein cleaved into hormones affecting pigmentation and stress

Proopiomelanocortin (POMC) is a large precursor protein that is produced in the pituitary gland and other tissues. It is cleaved into several important hormones, including adrenocorticotropic hormone (ACTH), which regulates cortisol production, and melanocyte-stimulating hormones (MSH), which influence skin pigmentation and hair growth.

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research Proopiomelanocortin expression in the skin during induced hair growth in mice

118 citations , January 1992 in “Experientia”

research Proopiomelanocortin (POMC) and Psychodermatology

11 citations , April 2023 in “Skin Health and Disease”

Psychological stress can worsen skin conditions like psoriasis and acne.

research A Founder Mutation in the POMC 5′-UTR Causes Proopiomelanocortin Deficiency Through Splicing-Mediated Decrease of mRNA

4 citations , July 2022 in “The Journal of Clinical Endocrinology & Metabolism”

A specific genetic mutation causes POMC deficiency, leading to symptoms like weight gain and red hair.

research Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol

489 citations , June 2005 in “The FASEB Journal”

Human hair follicles can produce cortisol like the body's stress response system.

Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth

research Melanogenesis is coupled to murine anagen: Toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth

210 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.

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learn Bimatoprost

a synthetic prostamide used to treat eyelashes also shows promise for stimulating hair growth on scalp

learn Latanoprost

glaucoma medication with hair follicle stimulant effects

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