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GlossaryMelanocortin 1 Receptor

regulates melanin production, affecting hair and skin color

The Melanocortin 1 Receptor (MC1R) is a protein found on the surface of melanocytes, the cells responsible for producing melanin, the pigment that gives skin, hair, and eyes their color. Variations in the MC1R gene can influence hair color, skin tone, and susceptibility to UV radiation, and are also associated with red hair and fair skin.

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research Detection of Functionally Active Melanocortin Receptors and Evidence for an Immunoregulatory Activity of α-Melanocyte-Stimulating Hormone in Human Dermal Papilla Cells

60 citations , August 2005 in “Endocrinology”

αMSH may help regulate immune responses in hair follicles and its disruption could lead to hair loss.

research Finasteride Inhibits Melanogenesis throughthe Regulation of Melanocortin 1 Receptorin Melanocytes

April 2015 in “한국생물공학회 학술대회”

Finasteride reduces melanin production in skin cells.

research Effect of Tribulus Terrestris Extract of Different Dosings on Melanocortin-1 Receptor Expression in Mouse Hair Follicles

January 2009 in “The Chinese Journal of Dermatovenereology”

Higher doses of Tribulus terrestris extract increase MC-1R expression in mouse hair follicles.

research Expression of melanocortin receptors on cutaneous fibroblastic cells – collagen and beyond

1 citations , January 2005 in “Experimental Dermatology”

MC-1R in skin cells may influence inflammation and collagen production.

Selected Variants of the Melanocortin 4 Receptor Gene (MC4R) Do Not Confer Susceptibility to Female Pattern Hair Loss

research Selected variants of the melanocortin 4 receptor gene (MC4R) do not confer susceptibility to female pattern hair loss

9 citations , November 2012 in “Archives of Dermatological Research”

MC4R gene variants not linked to female hair loss.

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