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GlossaryMitochondria

organelles generating energy for cellular functions

Mitochondria, often referred to as the "powerhouses of the cell," are organelles found in the cytoplasm of eukaryotic cells. They generate most of the cell's supply of adenosine triphosphate (ATP), which is used as a source of chemical energy. Mitochondria also play a role in other cellular processes such as signaling, cellular differentiation, and cell death, as well as maintaining control of the cell cycle and cell growth.

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learn PP405

mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

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learn Coenzyme Q10

learn Ubiquinone

learn Pichia minuta yeast

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Research

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research Mitochondrial dysfunction as a cause of ageing

384 citations , January 2008 in “Journal of Internal Medicine”

Mitochondrial dysfunction contributes to ageing by causing DNA mutations and reduced cell function.

research Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review

280 citations , July 2018 in “Antioxidants”

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

research Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

277 citations , February 2013 in “Science Signaling”

Mitochondrial reactive oxygen species are essential for skin and hair development.

research Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

222 citations , August 2014 in “Cell Metabolism”

Mitochondrial Complex I reduces inflammation and increases bone breakdown by affecting certain immune cells.

research Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients

198 citations , June 2013 in “Molecular psychiatry”

Schizophrenia patients' stem cells show abnormal neuron development and mitochondrial issues.

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Community Join

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community A science based addition to your hair loss routine

in Research/Science 23 upvotes 1 year ago

Blocking the Mitochondrial pyruvate carrier and using aldose reductase inhibitors like Indian gooseberry and berberine may help with hair growth. Magnesium can also be added to increase NADPH.

community The mechanism of androgenic alopecia

in Research/Science 34 upvotes 8 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

community PP405 Identity Research

in Research 292 upvotes 10 months ago

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 94 upvotes 6 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Poor man's PP405? Can't help but keep on thinking about this...

in Technology 6 upvotes 3 months ago

Lactic acid is not effective for hair growth when applied topically. JXL069, finasteride, and minoxidil are suggested as alternative treatments.

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