research Controlled Rigidity Nanolipogel-Mediated Topical Delivery of Fucosterol for Treating Androgenic Alopecia Through Follicle Targeting, Promoting Angiogenesis and Inhibiting Inflammation
This study presents a novel method for treating androgenetic alopecia (AGA) using a controlled rigidity nanolipogel (NLG) for the topical delivery of fucosterol. The NLG, with its lipid bilayer and alginate core, has its rigidity controlled by sodium alginate cross-linking. Among the tested formulations, the moderately rigid NLG-2.5 demonstrated superior transdermal permeability and hair follicle-targeting properties. It effectively inhibited inflammation and androgen pathways while promoting angiogenesis, leading to restored hair growth in AGA model mice. This approach offers promising insights for AGA treatment.
