Controlled Rigidity Nanolipogel-Mediated Topical Delivery of Fucosterol for Treating Androgenic Alopecia Through Follicle Targeting, Promoting Angiogenesis and Inhibiting Inflammation

    January 2026 in “ Biomacromolecules
    Gaodan Liu, Baihui Guo, Yang Pu, Jianyu Yang, M. Zhang, Peilong Sun, Simin Feng
    TLDR A new method using nanolipogels with fucosterol can help regrow hair by targeting follicles, reducing inflammation, and improving blood flow.
    The study introduces a novel method for treating androgenetic alopecia (AGA) using a controlled rigidity nanolipogel (NLG) for the topical delivery of fucosterol. The NLG, with a lipid bilayer and an alginate core, has its rigidity adjusted by sodium alginate cross-linking. Among the tested formulations, the moderately rigid NLG-2.5 demonstrated superior transdermal permeability and hair follicle-targeting properties. It effectively inhibited inflammation and androgen pathways while promoting angiogenesis, leading to restored hair growth in AGA model mice. This approach offers valuable insights for AGA treatment.
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