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Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

research Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites

18 citations , March 2020 in “Frontiers in Neuroendocrinology”

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

research Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABAA receptor subtypes

44 citations , February 2009 in “Pain”

Progesterone reduces spinal reflex activity by increasing certain GABA(A) receptor subtypes.

research Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System

1 citations , December 2021 in “Androgens”

Testosterone and its metabolites affect brain functions and could help treat neurological disorders.

Sexually Dimorphic Effect of Progesterone and Its Reduced Metabolites on the Gene Expression of Myelin Proteins in Rat Schwann Cells

research Sexually dimorphic effect of progesterone and its reduced metabolites on the gene expression of myelin proteins in rat Schwann cells

May 2006 in “Frontiers in Neuroendocrinology”

Progesterone and its metabolites affect myelin protein expression differently in male and female rat Schwann cells.

research Neuroactive Steroids: Functions, Mechanisms of Action and Physiologic Relevance

November 2003 in “Journal of Neurochemistry”

Allopregnanolone may enhance alcohol's effects on dopamine neurons, influencing addiction risk.

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community Finasteride does deplete important nuero-active steroids

in Research/Science 9 upvotes 2 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community risks with finasteride and dutasteride

in Research/Science 141 upvotes 1 year ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

in Finasteride/Dutasteride 26 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community 22M started fin/min/dermaroller again after stopping for almost 2 years (2months progress)

in Progress Pictures 35 upvotes 10 months ago

A 22-year-old resumed using finasteride, minoxidil, and a 0.5mm dermaroller after stopping for two years, experiencing positive results and improved mood. The discussion includes debates on the effects of finasteride on neurosteroids and the optimal dermaroller needle length for hair regrowth.

community Finasteride and “anti-aging” effects

in Treatment 218 upvotes 11 months ago

Finasteride may help users look younger by suppressing DHT, affecting skin and hair. Users also emphasize skincare, sunscreen, and lifestyle for maintaining a youthful appearance.

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