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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Progesterone reduces spinal reflex activity by increasing certain GABA(A) receptor subtypes.

Testosterone and its metabolites affect brain functions and could help treat neurological disorders.

Progesterone and its metabolites affect myelin protein expression differently in male and female rat Schwann cells.

Allopregnanolone may enhance alcohol's effects on dopamine neurons, influencing addiction risk.

Finasteride treatment can decrease certain steroids and increase others, possibly leading to depression symptoms in some cases.

Depressed teens have different steroid levels in urine, which may help identify and treat them.

Finasteride can cause lasting sexual and mood issues even after stopping the drug.

Men and women have different levels and production of brain steroids, which may affect their risk for certain brain disorders.

Pregnancy-related hormone changes affect Y1 receptor gene expression in mice.

Social isolation changes brain receptors and makes ethanol more impactful.

Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.

Finasteride blocks progesterone's effect on brain activity linked to epilepsy.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Neuroactive steroids affect cocaine's rewarding effects through the ς₁ receptor.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

Low dose finasteride decreases certain steroids, possibly increasing depression risk.

Short-term diabetes can cause changes in brain steroids, cholesterol balance, and mitochondrial function.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Finasteride use can cause lasting negative effects like sexual dysfunction, depression, anxiety, and cognitive issues.