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research The neurosteroid metabolite of progesterone, 3α‐OH‐dihydroprogesterone (3α‐OH‐DHP), is required for attenuated baroreflex mediated sympathoexcitation in pregnancy

1 citations , April 2013 in “The FASEB Journal”

3α‐OH‐DHP is essential for reducing nerve activity related to blood pressure control during pregnancy.

research Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABAA receptor subtypes

44 citations , February 2009 in “Pain”

Progesterone reduces spinal reflex activity by increasing certain GABA(A) receptor subtypes.

research Relating neurosteroid modulation of inhibitory neurotransmission to behaviour

18 citations , September 2021 in “Journal of Neuroendocrinology”

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

research Neurosteroid Synthesis-Mediated Regulation of GABA_AReceptors: Relevance to the Ovarian Cycle and Stress

238 citations , February 2007 in “Journal of Neuroscience”

Ovarian and stress hormones can change GABA A receptors through neurosteroids.

research Sex-specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids

22 citations , October 2019 in “Cerebral cortex”

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

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community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 2 years ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community Why do people here trust Kevin Mann?

in Chat 34 upvotes 6 years ago

Concerns about finasteride's side effects on neurosteroids and brain health, with skepticism towards Kevin Mann's advice. Users discuss using finasteride, minoxidil, and RU58841 for hair loss, with mixed opinions on their safety and effectiveness.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

in Finasteride/Dutasteride 26 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community 22M started fin/min/dermaroller again after stopping for almost 2 years (2months progress)

in Progress Pictures 35 upvotes 10 months ago

A 22-year-old resumed using finasteride, minoxidil, and a 0.5mm dermaroller after stopping for two years, experiencing positive results and improved mood. The discussion includes debates on the effects of finasteride on neurosteroids and the optimal dermaroller needle length for hair regrowth.

community risks with finasteride and dutasteride

in Research/Science 141 upvotes 1 year ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

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