January 2026 in “International Journal of Innovative Technologies in Social Science” Isotretinoin is highly effective for severe acne but can cause multisystem adverse effects due to its action on retinoic acid and retinoid X receptors. Common side effects include mucocutaneous reactions like cheilitis and xerosis, while hepatic enzyme elevations and dyslipidemia are dose-dependent but reversible. Musculoskeletal, ocular, and neuropsychiatric effects are rare and mild, though psychiatric monitoring is advised for at-risk individuals. Gastrointestinal and endocrine issues, such as subclinical hypothyroidism, are reported but not strongly linked to isotretinoin. Hematologic and renal changes are minor and temporary. The most significant risk is teratogenicity, necessitating strict contraceptive measures. Adverse effects are generally manageable with personalized dosing and monitoring, highlighting the importance of understanding these mechanisms for safe treatment.
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April 2006 in “Ocular Surface” Cosmetics and procedures can cause eye issues, from mild discomfort to serious conditions, due to allergies, toxins, or poor care.
278 citations
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May 2013 in “Ca” Targeted anticancer therapies can cause severe side effects similar to traditional chemotherapy, but with different types.
94 citations
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January 2007 in “Cutaneous and Ocular Toxicology” Iranian veterans exposed to sulfur mustard suffer from long-term skin itching and eye damage, with some risk of skin cancer and ongoing management challenges.
January 1987 in “Side effects of drugs annual” Some cosmetics and dermatological drugs can cause allergic reactions and side effects, like skin irritation and systemic issues.