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GlossaryOral Bioavailability

proportion of a substance absorbed into the bloodstream when ingested

Oral bioavailability refers to the proportion of a drug or substance that enters the bloodstream when it is taken by mouth and becomes available for use or storage in the body. It is a critical factor in determining the correct dosage for medications, as it affects how much of the active ingredient actually reaches the target tissues.

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Research

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Self-Microemulsifying Systems of Finasteride with Enhanced Oral Bioavailability: Multivariate Statistical Evaluation, Characterization, Spray-Drying and In Vivo Studies in Human Volunteers

research Self-microemulsifying systems of Finasteride with enhanced oral bioavailability: multivariate statistical evaluation, characterization, spray-drying and in vivo studies in human volunteers

39 citations , November 2015 in “Nanomedicine”

Improved Finasteride delivery for hair loss treatment.

research Design of a gelatin microparticle-containing self-microemulsifying formulation for enhanced oral bioavailability of dutasteride

16 citations , June 2015 in “Drug Design Development and Therapy”

The new formulation improves dutasteride's absorption when taken orally.

Optimization and Characterization of Cuscuta Reflexa Extract Loaded Phytosomes by the Box-Behnken Design to Improve the Oral Bioavailability

research Optimization and Characterization of Cuscuta reflexa Extract Loaded Phytosomes by the Box-Behnken Design to Improve the Oral Bioavailability

15 citations , January 2022 in “Journal of Oleo Science”

Phytosomal nanocarriers can significantly increase the bioavailability of Cuscuta reflexa extract.

research Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

260 citations , January 2019 in “Pharmaceutics”

Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.

research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib

184 citations , February 2015 in “EBioMedicine”

A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.

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Community Join

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community Is quercetin and houttunyia cordata extract actually effective for regrowth? Just heard of it for first time reading on Cleveland Clinic website

in Research/Science 5 upvotes 2 years ago

Quercetin and houttuynia cordata extract may stimulate hair growth by enhancing cellular energy metabolism and increasing growth factor secretion. Quercetin has low oral bioavailability, and its natural tint might stain the scalp if used topically.

community Sublingual Minoxidil - Cure to Hairloss?

in Minoxidil 583 upvotes 2 years ago

The conversation discusses the potential benefits of sublingual minoxidil for hair loss treatment. It suggests that sublingual minoxidil, which bypasses the liver, may have fewer side effects, greater bioavailability, and could be more effective than oral minoxidil.

community Oral minoxidil gives hair everywhere except scalp,plss help

in Minoxidil 41 upvotes 1 year ago

Oral minoxidil is causing body hair growth but not improving scalp hair, despite using dutasteride and finasteride. Users suggest waiting longer for results, checking vitamin levels, and considering additional treatments like topical minoxidil, dermarolling, and supplements.

community Oral Dut/Minoxidil for two years - no results.

in Treatment 102 upvotes 10 months ago

The user has used oral Dutasteride and Minoxidil for two years without regrowth, despite trying Finasteride and supplements. They consider increasing Minoxidil, adding microneedling, and switching medications, while others suggest RU58841, a hair transplant, or checking for other hair loss causes.

community My update oral min 2.5mg 23months dut 0.5mg EOD 14 months slow proggress

in Progress Pictures 22 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically oral minoxidil (2.5mg), dutasteride (0.5mg every other day), and ketoconazole. The user reports slow progress but significant hair growth after adding ketoconazole to their routine.

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Learn

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learn Dutasteride

Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Clinics

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