April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Developing hair follicles form from ring-shaped patterns, with future stem cells originating from the outer ring, not the upper layers, as previously thought.
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June 2013 in “Journal of Investigative Dermatology” Mice without certain skin proteins had abnormal skin and hair development.
February 2026 in “Biochemical and Biophysical Research Communications” This study demonstrates the successful regeneration of fully functional hair follicles using organ-inductive potential stem cells combined with an accessory mesenchymal cell population in an in vitro culture system. Researchers identified a specific cell population, PDGFRα+/Sca1+/CD34+ mesenchymal cells, from the boundary zone of the epithelial stem cell niche, which plays a crucial role in promoting the hair cycle's downgrowth phase. By reconstituting hair follicle germs from bulge region-derived epithelial stem cells, dermal papillae, and mesenchymal cells, the study achieved full-size hair follicle regeneration and hair cycling both in vitro and after skin transplantation. This research advances the understanding of adult organ-inductive potential stem cells and their niches, contributing to the fields of basic and medical science related to organ morphogenesis and the adult hair cycle.
December 2024 in “The Journal of Cell Biology” Basement membrane changes are crucial for hair follicle development.
November 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Scientists made a mouse that shows how a specific protein in the skin changes and affects hair growth and shape.