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GlossaryOsteoblasts

specialized cells responsible for bone formation and mineralization

Osteoblasts are specialized cells responsible for bone formation. They produce and secrete the matrix for bone and are crucial in the mineralization process, which helps in the development and maintenance of the skeletal system.

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research Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

222 citations , August 2014 in “Cell Metabolism”

Mitochondrial Complex I reduces inflammation and increases bone breakdown by affecting certain immune cells.

research Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts**This work was supported by NIDDK Grant DK-45227 and a scholarship (to R.C.P.) from Fundacao Coordenacao de Aperfeicoa mento de Pessoal de Nivel Superior (CAPES), Universidade de Sao Paulo (Sao Paulo, Brazil).

43 citations , January 1999 in “Endocrinology”

Cortisol increases a specific protein in bone cells, which may help explain its negative effects on bone.

research Bone vs. fat: Embryonic origin of progenitors determines response to androgen in adipocytes and osteoblasts

22 citations , October 2011 in “Bone”

Androgens affect bone and fat cell development differently based on the cells' embryonic origin.

research Induction of osteoblastic differentiation of neural crest-derived stem cells from hair follicles

17 citations , April 2017 in “PLoS ONE”

Hair follicle cells can become bone-like cells, useful for bone repair.

Ishige Sinicola Extract Stimulates Osteoblast Proliferation and Differentiation via the Bone Morphogenetic Protein 2/Runt-Related Gene 2 Signaling Pathway

research Ishige sinicola extract stimulates osteoblast proliferation and differentiation via the bone morphogenetic protein 2/runt-related gene 2 signalling pathway

4 citations , May 2019 in “Zeitschrift für Naturforschung C”

Ishige sinicola extract helps bone-building cells grow and mature, which could aid in treating osteoporosis.

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