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GlossaryOsteoblasts

specialized cells responsible for bone formation and mineralization

Osteoblasts are specialized cells responsible for bone formation. They produce and secrete the matrix for bone and are crucial in the mineralization process, which helps in the development and maintenance of the skeletal system.

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research Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

222 citations , August 2014 in “Cell Metabolism”

Mitochondrial Complex I reduces inflammation and increases bone breakdown by affecting certain immune cells.

research Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts**This work was supported by NIDDK Grant DK-45227 and a scholarship (to R.C.P.) from Fundacao Coordenacao de Aperfeicoa mento de Pessoal de Nivel Superior (CAPES), Universidade de Sao Paulo (Sao Paulo, Brazil).

43 citations , January 1999 in “Endocrinology”

Cortisol increases a specific protein in bone cells, which may help explain its negative effects on bone.

research Bone vs. fat: Embryonic origin of progenitors determines response to androgen in adipocytes and osteoblasts

22 citations , October 2011 in “Bone”

Androgens affect bone and fat cell development differently based on the cells' embryonic origin.

research Induction of osteoblastic differentiation of neural crest-derived stem cells from hair follicles

17 citations , April 2017 in “PLoS ONE”

Hair follicle cells can become bone-like cells, useful for bone repair.

Ishige Sinicola Extract Stimulates Osteoblast Proliferation and Differentiation via the Bone Morphogenetic Protein 2/Runt-Related Gene 2 Signaling Pathway

research Ishige sinicola extract stimulates osteoblast proliferation and differentiation via the bone morphogenetic protein 2/runt-related gene 2 signalling pathway

4 citations , May 2019 in “Zeitschrift für Naturforschung C”

Ishige sinicola extract helps bone-building cells grow and mature, which could aid in treating osteoporosis.

Comparison of Three Different Lactic Acid Bacteria-Fermented Proteins on RAW 264.7 Osteoclast and MC3T3-E1 Osteoblast Differentiation

research Comparison of three different lactic acid bacteria-fermented proteins on RAW 264.7 osteoclast and MC3T3-E1 osteoblast differentiation

December 2023 in “Scientific reports”

Fermented soy protein may help prevent bone loss by affecting bone cell activity.

research Skeletal Site-Dependent Expression of the Androgen Receptor in Human Osteoblastic Cell Populations

123 citations , December 1997 in “Calcified Tissue International”

Higher androgen levels and site-specific AR expression cause sex-related skeletal differences, and certain steroids can boost AR expression and androgen effects in bone cells.

research Human Osteoblast-Like Cells Express Predominantly Steroid 5α-Reductase Type 1

56 citations , December 2002 in “The Journal of Clinical Endocrinology & Metabolism”

Human bone cells mainly produce a type 1 enzyme that may help regulate bone health.

research Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice

21 citations , September 2003 in “Journal of Clinical Investigation”

Overexpressing noggin in mice causes severe osteoporosis.

research Effects of dihydrotestosterone on osteoblast activity in curdlan-administered SKG mice and osteoprogenitor cells in patients with ankylosing spondylitis

8 citations , May 2020 in “Arthritis research & therapy”

DHT inhibition may increase spinal bone growth in ankylosing spondylitis.

Comparison of Differentiated Osteoblasts from Adipose Stem Cells and Normal Osteoblasts

research Comparison differentiated osteoblast from adipose stem cells and normal osteoblast

September 2011 in “Clinical Biochemistry”

Glycoconjugates help heal hair follicles during skin repair.

research Wedelolactone inhibits breast cancer-induced osteoclastogenesis by decreasing Akt/mTOR signaling

53 citations , November 2014 in “International Journal of Oncology”

Wedelolactone may help prevent bone damage in breast cancer by blocking certain cell signals.

research The effects of synthetic 19-norprogestins on osteoblastic cell function are mediated by their non-phenolic reduced metabolites

13 citations , May 2007 in “Journal of Endocrinology”

Synthetic 19-norprogestins promote bone cell growth and function through their non-phenolic metabolites.

research Cryptotanshinone Suppressed Postmenopausal Osteoporosis by Preventing RANKL-Mediated Osteoclastogenesis against Kidney Injury

14 citations , January 2022 in “Evidence-based Complementary and Alternative Medicine”

Cryptotanshinone may help treat postmenopausal osteoporosis and protect kidneys.

Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

research Androgen receptor activation integrates complex transcriptional effects in osteoblasts, involving the growth factors TGF-β and IGF-I, and transcription factor C/EBPδ

11 citations , July 2015 in “Gene”

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

research Synergistic Effect of Stauntonia hexaphylla (Thunb.) Decne Fruit and Leaf on RAW 264.7 Osteoclast and MC3T3-E1 Osteoblast Differentiation

1 citations , June 2025 in “Biomolecules”

Stauntonia hexaphylla leaves and fruits, especially leaves, may help prevent osteoporosis by boosting bone growth and reducing bone loss.

Deletion of DNA Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

research Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

277 citations , July 2002 in “Molecular Endocrinology”

Removing part of the vitamin D receptor stops vitamin D from working properly.

Cartilage to Bone Transformation During Fracture Healing Is Coordinated by the Invading Vasculature and Induction of the Core Pluripotency Genes

research Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes

160 citations , January 2017 in “Development”

Blood vessels and specific genes help turn cartilage into bone when bones heal.

research Comparative Characterization of Hair Follicle Dermal Stem Cells and Bone Marrow Mesenchymal Stem Cells

151 citations , February 2006 in “Stem Cells and Development”

Hair follicles can be a good source of stem cells like those from bone marrow.

research Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart

125 citations , August 2003 in “Development”

Mice with human-like EGFR had growth issues, skin defects, heart problems, and unusual bone development.

research Lamins in development, tissue maintenance and stress

64 citations , November 2012 in “EMBO reports”

Lamins are vital for cell survival, organ development, and preventing premature aging.

research A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

57 citations , June 2021 in “Polymers”

Photothermal hydrogels are promising for infection control and tissue repair, and combining them with other treatments could improve results and lower costs.