research Role of plasminogen activator inhibitor type 1 (PAI-1) in PCOS patient
People with PCOS have higher levels of PAI-1, which may increase their risk of heart disease and fertility issues.
Search
forResearch
5 / 611 results 
research Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women
Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.
research Thrombin activatable fibrinolysis inhibitor and other hemostatic parameters in patients with polycystic ovary syndrome
Women with PCOS have higher levels of certain blood clotting factors, suggesting a greater risk of cardiovascular issues.
research Wound healing in development
Wounds heal without scarring in early development but later result in scars, and studying Wnt signaling could help control scarring.
research Evaluation of cardiac risk marker levels in obese and non-obese patients with polycystic ovaries
Obese and non-obese women with PCOS have higher heart risk markers, especially if they are obese.
Community Join
5 / 21 resultscommunity How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.
ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.
community ICYMI: Eirion ET-02’s Successful Phase 1 Trial Results for Androgenic Alopecia Treatment
ET-02 showed significant hair growth in five weeks, outperforming minoxidil, with a non-hormonal mechanism that avoids side effects of treatments like finasteride. A phase 2 trial is planned to further assess ET-02's efficacy and safety.
community Initial thoughts on the Happy Head SuperCapsule (oral min/fin and oral min/dut compounds)
The user noticed increased hair fullness after using a minoxidil and finasteride oral capsule but is unsure if the 1.25 mg minoxidil dose is sufficient. They are considering switching to a higher dose and are waiting for a dermatologist's advice.
community Why does Pelage PP405 receive so much attention, while Eirion ET-02 seems to be almost forgotten?
ET-02 is seen as promising for addressing hair loss and graying, but PP405 is more advanced in development and has better publicity. Some users plan to use both treatments alongside minoxidil and dutasteride.
community Anyone is going to test if verteporfin work in the upper area or demaroller + verteporfin?
The conversation is about the interest in testing verteporfin, potentially with a dermaroller, for hair loss treatment. There is frustration over the lack of group buys for promising treatments compared to past efforts with less evidence.
Learn
2 / 801 resultslearn Setipiprant
learn PP405
mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials
Clinics
6 / 9 results- 51Hair Loss TreatmentsHair TransplantPAI Medical Hair RestorationRegina, SK · CA
- 13
Hair TransplantHair Loss TreatmentsPAI MedicalOttawa, ON · CA - 46Hair SystemsPAI Medical ClevelandCleveland, OH · US
- 56
Hair TransplantHair Loss TreatmentsSMPWe Grow Hair - PAI Medical GroupBrentwood, TN · US - 78
Hair Loss TreatmentsDr Jamuna Pai's SkinLab ClinicJebel Ali · AE - 9Hair TransplantSMPHair Loss TreatmentsGreffe Cheveux PAIQuébec, QC · CA
