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GlossaryPAPA Syndrome

rare genetic disorder causing arthritis, skin ulcers, and severe acne

PAPA Syndrome, or Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne Syndrome, is a rare genetic disorder characterized by recurrent episodes of joint inflammation (arthritis), painful skin ulcers (pyoderma gangrenosum), and severe acne. It is caused by mutations in the PSTPIP1 gene, which affects the immune system and leads to excessive inflammation.

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Research

5 / 293 results

research Prenatal Androgenization of Ewes as a Model of Hirsutism in Polycystic Ovary Syndrome

6 citations , October 2018 in “Endocrinology”

Prenatally androgenized ewes can model increased hair diameter in women with PCOS.

research Acne and Systemic Disease

76 citations , November 2009 in “Medical Clinics of North America”

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

research Acne as a chronic systemic disease

71 citations , November 2013 in “Clinics in Dermatology”

Acne is a chronic disease linked to various systemic conditions and has significant psychological and social effects.

research Difficult and rare forms of acne

18 citations , October 2016 in “Clinics in Dermatology”

The document talks about hard-to-treat and rare acne types, their connection with other health issues, the importance of correct diagnosis, and the challenges in managing them.

research Commentary 2

January 2005 in “Experimental Dermatology”

Genetic factors play a major role in acne.

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Community Join

2 / 1000+ results

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I just made my own PRP - DIY PRP

in Research/Science 552 upvotes 2 years ago

The post and conversation are about a user who made their own Platelet-Rich Plasma (PRP) for hair loss treatment at home, using their own blood and a centrifuge. The responses vary, with some users supporting the DIY approach to save money, others expressing concern about the safety and effectiveness of the method, and a few joking about the lengths people will go to combat hair loss.

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