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research Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ

218 citations , October 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

research Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk

102 citations , July 2007 in “Genes & Development”

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

research Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth

51 citations , September 2000 in “Acta dermato-venereologica”

PPAR alpha may help in hair growth and could be a target for treatment.

research Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation?

28 citations , November 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

GMG-43AC may help reduce unwanted hair growth and treat certain hair loss conditions.

PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology

research PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology

24 citations , November 2019 in “Experimental Dermatology”

PPAR-γ is important for healthy hair and its problems, and more research on PPAR-γ treatments is needed.

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community DHT Oily Scalp Dangers: Theory of an Oily Scalp and PPAR-GAMMA Dysregulation

in Research/Science 32 upvotes 1 year ago

Excessive scalp sebum, worsened by DHT, can lead to inflammation and hair loss, with clascoterone mentioned as a treatment. Diet changes seem ineffective for scalp sebum, and treatments like minoxidil and finasteride are suggested.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 93 upvotes 4 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

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