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5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

research 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

110 citations , August 2015 in “Neuropsychopharmacology”

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

Are There Temporal Subtypes of Premenstrual Dysphoric Disorder? Using Group-Based Trajectory Modeling to Identify Individual Differences in Symptom Change

research Are there temporal subtypes of premenstrual dysphoric disorder?: using group-based trajectory modeling to identify individual differences in symptom change

19 citations , April 2020 in “Psychological Medicine”

The study found three different timing patterns of symptoms in women with premenstrual dysphoric disorder.

research Double Dosing

2 citations , October 2002 in “American Journal of Nursing”

Taking the same medication under different brand names caused harmful side effects.

research Desideratum dermatologicum--cause and control of premenstrual acne flare

11 citations , May 2000 in “International Journal of Dermatology”

Taking a small dose of prednisone before menstruation can almost completely prevent premenstrual acne with few side effects.

research Examination of premenstrual syndrome in patients with polycystic ovary syndrome

January 2026 in “Journal of Contemporary Studies in Epidemiology and Public Health”

Women with PCOS often have severe PMS, but managing anemia and regular menstruation can help reduce symptoms.

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community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 2 years ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community Finasteride does deplete important nuero-active steroids

in Research/Science 9 upvotes 2 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

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