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GlossaryProgerin

defective protein causing premature aging in Hutchinson-Gilford Progeria Syndrome

Progerin is a defective protein that is produced in cells due to a mutation in the LMNA gene, which normally codes for the lamin A protein. This abnormal protein is associated with Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic disorder that causes accelerated aging in children. Progerin disrupts the normal structure and function of the cell nucleus, leading to various symptoms of premature aging.

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research Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease

85 citations , March 2008 in “Journal of Cell Science”

The mutation causing Hutchinson-Gilford progeria syndrome leads to severe skin problems and early death in mice.

research Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells

51 citations , October 2019 in “Cells”

Baricitinib reduces inflammation and improves cell health in premature aging cells.

research Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin

48 citations , April 2008 in “Human Molecular Genetics”

Progerin affects cell shape but not hair or skin in mice.

research Hutchinson-Gilford Progeria Syndrome—Current Status and Prospects for Gene Therapy Treatment

39 citations , January 2019 in “Cells”

Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.

research Endoplasmic reticulum stress at the crossroads of progeria and atherosclerosis

11 citations , March 2019 in “EMBO molecular medicine”

A defective protein in progeria causes cell death and atherosclerosis, but a treatment targeting cell stress may reduce these effects.

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community Saw Palmetto/Pumkin seed gives basically same results as Fin

in Treatment 1 year ago

A user reported that Procerin, containing Saw Palmetto and Pumpkin seed oil, provided similar hair thickening results as finasteride but with milder side effects. They experienced reduced libido and watery ejaculations but are adjusting the dose to minimize these effects.

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