Proopiomelanocortin (POMC) and Psychodermatology

    April 2023 in “ Skin Health and Disease
    G. W. M. Millington, Hannah E. Palmer
    TLDR Psychological stress can worsen skin conditions like psoriasis and acne.
    Psychodermatology explores the intersection of dermatology and psychology/psychiatry, focusing on how psychiatric conditions can manifest in the skin and how skin diseases can lead to psychological issues. The study highlights the role of the hypothalamic-pituitary-adrenal axis and the cutaneous corticotrophin-releasing factor-proopiomelanocortin-corticosteroid axis in these interactions. Disruptions in these systems can exacerbate immune-related skin conditions like psoriasis, atopic eczema, acne, alopecia areata, vitiligo, and melasma, which are often stress-related. The paper emphasizes the importance of considering skin color, especially in pigmentary disorders, in the context of psychodermatology.
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