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    GlossaryRAF inhibitors

    block proteins involved in cell growth signaling pathways

    RAF inhibitors, also known as RAF kinase inhibitors, are a class of drugs designed to block the activity of RAF kinases, which are proteins involved in cell signaling pathways that control cell growth and division. These inhibitors are particularly important in the treatment of certain cancers, such as melanoma, where mutations in the RAF gene (e.g., BRAF mutations) lead to uncontrolled cell proliferation. By inhibiting RAF kinases, these drugs can help to slow down or stop the growth of cancer cells.

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      learn Pyrilutamide

      highly targeted anti-androgen that might have minimal systemic effects

      learn Tofacitinib

      a JAK inhibitor for alopecia areata and other autoimmune conditions

      learn RU58841

      a potent but unapproved and potentially problematic topical anti-androgen

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      community Androgen degraders for hair loss

      in Research/Science  60 upvotes 1 year ago
      The conversation discusses androgen receptor degraders for hair loss, highlighting their potential advantages over traditional AR blockers like RU58841 and pyrilutamide. Concerns about the safety and cost of these treatments are also mentioned.

      community Fevipiprant 2019!

       15 upvotes 9 years ago
      The conversation discusses Fevipiprant, an asthma drug that may block CRTH2 and potentially stop male pattern baldness (MPB) without inhibiting DHT. It also mentions the use of finasteride and dutasteride for hair loss.

      community Can aromatase inhibitors make dutasteride/finasteride useless?

      in Finasteride/Dutasteride  9 upvotes 2 years ago
      The conversation discusses using aromatase inhibitors with dutasteride or finasteride for hair loss, which can prevent testosterone from turning into estrogen but may lead to increased DHT and potentially make finasteride less effective. There's concern about proper dosing and side effects like gynecomastia and emotional changes.

      community Sensitive to Oral fin + RU. Am I screwed?

      in Product  4 upvotes 4 years ago
      Akinfenrawr experienced negative side effects from oral finasteride and RU58841, and is seeking alternative hair loss treatments. They discuss various options, including raloxifene, oral dutasteride, liposomal finasteride, Breezula, Pyrilutamide, SM04554, and sulforaphane, but have concerns about efficacy, availability, and cost.