199 citations
,
January 2004 in “The International Journal of Developmental Biology” This review discusses advances in understanding hair and hair follicle structure, gene expression, and molecular signals in hair formation, without reporting new clinical findings.
198 citations
,
May 2021 in “Advanced Materials” This review discusses triboelectric nanogenerator (TENG) devices for body-integrated electrical stimulation therapy and suggests they may revolutionize personalized healthcare, but it reports no new clinical results.
198 citations
,
April 2020 in “Journal of Endocrinological Investigation” This study found no SARS-CoV-2 RNA in the semen and urine of a COVID-19 patient, suggesting possible viral clearance or absence in these fluids.
198 citations
,
June 2013 in “Molecular psychiatry” This study found that schizophrenia-derived neurons exhibited impaired differentiation and mitochondrial dysfunction, suggesting a potential link between these factors and neurodevelopmental processes in schizophrenia.
198 citations
,
October 2011 in “Journal der Deutschen Dermatologischen Gesellschaft” This article discusses the development of an evidence-based guideline for treating androgenetic alopecia and reports no new research results.
198 citations
,
July 2011 in “Cochrane library” This study found that lifestyle interventions improved body composition, hyperandrogenism, and insulin resistance in women with PCOS, but did not affect glucose tolerance, lipid profiles, or clinical reproductive outcomes.
198 citations
,
September 2007 in “Clinics in Dermatology” Radiofrequency devices effectively tighten skin without surgery.
198 citations
,
March 1999 in “Journal of Investigative Dermatology” This study found that keratin 15 expression is downregulated in hyperproliferative conditions like psoriasis and hypertrophic scars, suggesting it is not compatible with keratinocyte activation.
198 citations
,
January 1998 in “Dermatology” This review discusses human sebocyte in vitro models for studying sebaceous gland function and control but reports no new clinical results, highlighting hormonal effects and the impact of retinoids on sebocyte activity.
198 citations
,
November 1989 in “The Journal of Cell Biology” This study reported that K14 expression patterns and keratin filament organization in human skin's hair follicles differ from those in the epidermis, indicating distinct differentiation programs.
198 citations
,
October 1986 in “Differentiation” 197 citations
,
January 2019 in “Neuropsychopharmacology” This review discusses sex differences in the neuroendocrine response to stress, focusing primarily on rodent studies, and highlights open questions about the roles of gonadal hormones and sex chromosomes.
197 citations
,
June 2009 in “American journal of human genetics” This study found that previously undescribed WNT10A mutations are a prominent cause of various forms of ectodermal dysplasia, including OODD and Schöpf-Schulz-Passarge syndrome, with gender-specific phenotypic effects noted.
196 citations
,
December 2017 in “Phytotherapy Research” This review discusses the bioactive phytochemical and biological activities of Psoralea corylifolia, emphasizing its potential therapeutic uses, and reports no new clinical results; the authors call for further clinical trials.
196 citations
,
September 2016 in “JCI insight” This study explored the effectiveness of the oral JAK1/2 inhibitor ruxolitinib in treating patients with moderate-to-severe alopecia areata, building on prior success with JAK inhibitors in mice, but results are not reported in this abstract.
196 citations
,
March 2016 in “Nature Communications” In this study, researchers identified 18 genetic associations with scalp and facial hair traits in Latin Americans, including novel loci for hair greying and balding, with implications for understanding hair evolution.
196 citations
,
November 2014 in “PubMed” This article discusses the diagnosis and treatment of tinea infections, emphasizing the importance of confirming certain diagnoses with lab tests and recommending treatments such as terbinafine for tinea capitis and onychomycosis.
196 citations
,
June 2008 in “International Journal of Dermatology” This study found that dermoscopic indicators like black dots and tapering hairs are valuable markers for diagnosing and assessing the severity and activity of alopecia areata in Asian patients.
196 citations
,
May 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that SZ95 sebocytes and HaCaT keratinocytes exhibit distinct enzyme expressions and activities, implicating their different roles in androgen metabolism and homeostasis in vitro.
195 citations
,
November 2019 in “Clinica Chimica Acta” This review discusses the interplay of hyperandrogenism, insulin resistance, obesity, and their role in polycystic ovary syndrome, but presents no new clinical results.
195 citations
,
December 2009 in “Journal of Investigative Dermatology” This study found that sebum free fatty acids may enhance the antibacterial defense of human sebaceous glands by upregulating the expression of the antimicrobial peptide hBD-2, potentially aiding in acne treatment.
195 citations
,
January 2008 in “Photochemistry and Photobiology” This review discusses the effects of visible light on human skin, highlighting its role in pigmentation, thermal damage, and the treatment of several skin conditions, while noting limited sunscreen protection against it; no new clinical results are reported.
195 citations
,
February 2007 in “The Journal of Clinical Endocrinology and Metabolism” In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.
195 citations
,
June 2005 in “American Journal of Human Genetics” Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.
195 citations
,
February 2005 in “Journal of biological chemistry/The Journal of biological chemistry” This study shows that ZIP7 is a functional zinc transporter in mammalian cells, facilitating the movement of zinc from the Golgi apparatus to the cytoplasm.
195 citations
,
May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology” This review discusses the diagnosis and treatment of hirsutism, emphasizing that a systematic evaluation can determine its cause, while combination therapy effectively manages the condition for most patients.
195 citations
,
November 2001 in “The Journal of Cell Biology” This study found that desmocollin 1 is crucial for strong adhesion and barrier maintenance in the mouse epidermis, with its absence leading to skin and hair issues resembling chronic dermatitis.
194 citations
,
October 2018 in “Microbiome” This study examined recent findings on the role of host-microbiome interactions in acne, highlighting that the skin's microbiome composition differs between acne-affected and healthy individuals and discussing emerging microbiome-based treatments.
194 citations
,
February 2015 in “Development” This review discusses the Activin/Nodal signalling pathway's role in stem cell function and its implications in cancer therapy, reporting no new experimental results but highlighting future research questions.
194 citations
,
November 2006 in “Science” This study identified a gene mutation in the LIPH gene associated with inherited hair loss and hair growth defects in certain populations, suggesting lipase H plays a role in hair development.