205 citations
,
August 2007 in “Experimental Cell Research” This review discusses advances in understanding mammalian stem cell niches, particularly in bone marrow, tooth, and hair follicle, and highlights the potential for developing therapies targeting these niches for tissue repair.
205 citations
,
April 2005 in “Journal of Investigative Dermatology” This study describes a system for generating hair follicles from dissociated cells in mice, suggesting that successful development requires a foundational epithelial platform.
205 citations
,
January 2005 in “Skin pharmacology and physiology” This review discusses how liposomes and niosomes can enhance drug penetration in topical delivery systems and emphasizes the importance of their specific composition, size, and type, but it reports no new results.
204 citations
,
May 2014 in “The Journal of Sexual Medicine” This study concluded that current cross-sex hormone treatments for trans men and trans women are effective with a low risk of side effects in the short term, though they did observe specific clinical changes.
204 citations
,
February 2000 in “Current Medicinal Chemistry” This review discusses the use of antiandrogens like flutamide and its derivatives in prostate cancer treatment and highlights the need for next-generation antiandrogens for improved efficacy; it reports no new clinical results.
204 citations
,
October 1999 in “EMBO journal” This study found that overexpression of activin in transgenic mice led to enhanced granulation tissue formation after skin injury due to changes in keratinocyte proliferation and differentiation.
203 citations
,
May 2022 in “Pharmaceutics” This review discusses ongoing concerns and advancements in the use of gelatin as a biomaterial in tissue engineering, highlighting improved tissue mimicry through techniques like 3D bioprinting and suggesting a future focus on disease detection and diagnosis rather than treatment.
203 citations
,
July 2017 in “Biotechnology and Genetic Engineering Reviews” This review discusses the various components essential for successful tissue engineering, such as cell sources, modification methods, and supportive matrices, and highlights the need for functional synergy without reporting new experimental results.
203 citations
,
May 2017 in “Journal of controlled release” This review discusses completed and ongoing clinical studies on microneedle-based technologies for cosmetic, therapeutic, and diagnostic applications and reports no new clinical results.
203 citations
,
December 2004 in “Journal of The American Academy of Dermatology” This article reviews the historical developments in understanding and treating male pattern hair loss, emphasizing the role of dihydrotestosterone and 5α-reductase inhibitors, but reports no new clinical findings.
203 citations
,
June 2003 in “Journal of the American Academy of Dermatology” This article reviews the structure and chemistry of hair across ethnicities and how these factors affect hair properties and treatment responses, but reports no new research findings.
203 citations
,
November 1984 in “Journal of the American Academy of Dermatology” This study presents evidence suggesting that androgenetic alopecia is most likely inherited through a polygenic model, challenging the traditional view that it is caused by a simple Mendelian autosomal dominant gene.
203 citations
,
December 1947 in “Annals of Internal Medicine” This lecture discusses osteoporosis and its connection to internal skeletal dynamics but reports no new research findings.
202 citations
,
July 2022 in “Biomedicine & Pharmacotherapy” This review compiles and discusses the ethnomedicinal uses, pharmacological activities, and phytochemistry of pomegranate, suggesting potential future applications in drug discovery for various ailments but reports no new clinical results.
202 citations
,
January 2022 in “Journal of Clinical Medicine” This study found that female COVID-19 survivors were more likely than males to experience multiple long-term post-COVID symptoms, including fatigue, pain, hair loss, and mood disorders.
202 citations
,
August 2017 in “Nature cell biology” This study found that glycolytic metabolism and lactate production are crucial for hair follicle stem cell activation, and manipulating these processes can stimulate the hair cycle.
202 citations
,
August 2007 in “Biomaterials” This review discusses advancements in artificial skin for wound treatment and reports no new clinical findings; the authors highlight the potential of new biomaterials to enhance future skin replacement therapies.
202 citations
,
June 2005 in “Aaps Pharmscitech” This review discusses the potential of lecithin organogels for improving topical drug delivery and presents no new experimental results; the authors highlight their stability and low skin irritancy as advantages.
202 citations
,
January 1989 in “Journal of Clinical Investigation” This study indicates that insulin changes sex hormone levels in insulin-resistant women with polycystic ovary syndrome without affecting gonadotropin release, challenging the idea that hyperinsulinemia directly causes hyperandrogenism in PCO.
201 citations
,
April 2017 in “Regeneration” This review examines the roles of macrophages and fibroblastic cells in organ injury and repair, discussing their impact on outcomes ranging from regeneration to fibrosis, without presenting new clinical results.
201 citations
,
August 2006 in “Cell and Tissue Research” 201 citations
,
November 2002 in “Annals of internal medicine” This guideline discusses evidence-based recommendations for managing acute migraine attacks and preventing migraines, highlighting effective treatments such as NSAIDs and triptans but reports no new clinical findings.
201 citations
,
May 2001 in “Proceedings of the National Academy of Sciences” This study found that transgenic expression of COX-2 in mouse basal keratinocytes causes epidermal hyperplasia and certain dysplastic features at specific body sites.
201 citations
,
November 1964 in “Journal of neurophysiology” The cuneate nucleus has two main neuron types: relay neurons and interneurons.
200 citations
,
March 2023 in “Nature Reviews Molecular Cell Biology” This review discusses the role and regulation of quiescent adult stem cells in tissue maintenance and repair, focusing on molecular mechanisms and their implications for regenerative medicine, but reports no new clinical results.
200 citations
,
October 2009 in “European journal of endocrinology” This review discusses the multifaceted actions of metformin in polycystic ovary syndrome and reports no new clinical results; the authors emphasize metformin's potential benefits in both cardiometabolic and reproductive aspects of PCOS.
200 citations
,
August 2009 in “Experimental dermatology” This article reviews the role of IGF-1 in acne pathogenesis and discusses how diet and smoking may influence insulin/IGF-1 signaling, but reports no new clinical results.
200 citations
,
November 1997 in “Planta” This study found that while a tip-focused calcium gradient influences localized growth in root hairs and pollen tubes, it is not the primary determinant of growth direction in root hairs of Arabidopsis thaliana.
199 citations
,
April 2010 in “Nature” A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.
199 citations
,
July 2007 in “General and Comparative Endocrinology” In this study, researchers found a significant positive association between cortisol levels in hair and feces of domestic cats and dogs, suggesting hair cortisol assays could be a viable option for monitoring chronic stress.