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research Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

53 citations , July 2009 in “Cancer Research”

Blocking certain proteins can reduce skin inflammation caused by cancer treatment.

research Type 1 interferon signature in the scalp lesions of alopecia areata

52 citations , March 2010 in “British Journal of Dermatology”

Alopecia areata shows a unique type 1 interferon signature, suggesting potential treatment by targeting this pathway.

research Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase

52 citations , January 2003 in “Journal of Investigative Dermatology”

Thrombospondin-1 is crucial for hair follicle regression and reduced blood vessel growth during the catagen phase.

research Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino-Acid Composition and Repeat Structure

51 citations , January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists discovered a unique hair protein, KAP24.1, with a special structure, found only in the upper part of hair cuticles.

research Selective non-steroidal inhibitors of 5α-reductase type 1

49 citations , January 2004 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia

research The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia

49 citations , August 2003 in “Journal of The American Academy of Dermatology”

Higher IGF-1 levels in hair follicles link to better finasteride results for hair loss.

research Characterization and expression analysis of KAP7.1, KAP8.2 gene in Liaoning new-breeding cashmere goat hair follicle

48 citations , February 2010 in “Molecular biology reports”

KAP7.1 and KAP8.2 genes are crucial for cashmere quality in goats.

Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride

45 citations , August 2010 in “Hormone Molecular Biology and Clinical Investigation”

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

research Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration

44 citations , June 2023 in “Cell Reports”

IL-1 promotes fat cell growth in skin, while WNT inhibits it and encourages scar formation.

research Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle.

44 citations , August 1990 in “PubMed”

Keratins K1 and K10 are found in the inner root sheath and cuticle of human hair follicles.

Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

research Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

43 citations , December 2013 in “Stem Cells”

Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.

Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells

research Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells

42 citations , February 2017 in “Scientific Reports”

Researchers found a way to create cells from stem cells that act like human cells important for hair growth and could be used for hair regeneration treatments.

research Identification of the Ovine Keratin-Associated Protein 22-1 (KAP22-1) Gene and Its Effect on Wool Traits

42 citations , January 2017 in “Genes”

The gene KAP22-1 affects wool yield and fiber shape in sheep.

research Evaluation of efficacy and safety of finasteride 1 mg in 3177 Japanese men with androgenetic alopecia

41 citations , October 2011 in “Journal of Dermatology”

Finasteride 1 mg effectively and safely increases hair growth in Japanese men with hair loss.

research Tight Junction barriers in human hair follicles – role of claudin-1

39 citations , August 2018 in “Scientific reports”

Claudin-1 is important for the barrier function and growth of hair.

research Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells

39 citations , December 2011 in “PLoS ONE”

Radiofrequency exposure can stimulate hair growth by increasing IGF-1 in hair follicle cells.

research Krtap11-1, a hair keratin-associated protein, as a possible crucial element for the physical properties of hair shafts

38 citations , January 2014 in “Journal of Dermatological Science”

Krtap11-1 is important for hair strength and structure.

research Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture

38 citations , March 1997 in “Journal of interferon & cytokine research”

IL-1β inhibits human hair follicle growth.

research Glucagon-like peptide-1 receptor and proglucagon expression in mouse skin

37 citations , March 2006 in “Regulatory Peptides”

Mice skin has components that could help with hair growth and might be used for diabetes treatment.

research Message of nexin 1, a serine protease inhibitor, is accumulated in the follicular papilla during anagen of the hair cycle

37 citations , December 1995 in “Journal of Cell Science”

Nexin 1 may help control hair growth.

WISP-1 Induced by Mechanical Stress Contributes to Fibrosis and Hypertrophy of the Ligamentum Flavum Through Hedgehog-Gli1 Signaling

research WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling

36 citations , June 2021 in “Experimental & Molecular Medicine”

Targeting Hedgehog signaling may help treat ligamentum flavum fibrosis.

research Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars

36 citations , February 2016 in “British journal of pharmacology”

Sirtuin 1 could be a potential drug target for treating hypertrophic scars.

research Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling

35 citations , June 2012 in “PloS one”

Keratin 15 expression in skin cells is regulated by two mechanisms involving PKC/AP-1 and FOXM1.

Adult Epidermal Notch Activity Induces Dermal Accumulation of T Cells and Neural Crest Derivatives Through Upregulation of Jagged 1

research Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1

34 citations , November 2010 in “Development”

Activating Notch in adult skin causes T cells and neural crest cells to gather, leading to skin issues.

research l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

34 citations , March 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

research Interleukin-1β-Induced Inhibition of Hair Growth In Vitro Is Mediated by Cyclic AMP

33 citations , January 1997 in “Journal of Investigative Dermatology”

research Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10.

33 citations , March 1994 in “PubMed”

High ODC and low K1 and K10 may indicate early skin tumors in mice.

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