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Growth hormone therapy can improve symptoms and growth in children with Vitamin-D Dependent Rickets Type-2.

Anabolic steroids and inflammation can disrupt androgen metabolism, potentially causing health issues.

A new genetic mutation in the ODC1 gene causes developmental delay and other symptoms in a young girl.

HLD10 can include increased body hair and Mongolian spots.

Finasteride effectively inhibits the enzyme steroid 5 alpha-reductase II.

Hoyeraal-Hreidarsson syndrome in infants causes severe gastrointestinal issues.

Women with hyperandrogenism have higher androgen levels and lower SHBG, which may contribute to conditions like excessive hair growth and early puberty.

Women with nonclassic 21-hydroxylase deficiency can have successful pregnancies through IVF, with certain factors affecting their chances.

Three siblings with a genetic form of rickets showed different symptoms of the disease.

People who carry the 21-Hydroxylase Deficiency gene are not more likely to have excessive male hormone levels.

HVDRR is caused by VDR gene mutations, leading to vitamin D resistance, treatable with high calcium doses, but alopecia remains permanent.

5α-reductase deficiency can cause ambiguous genitalia and gender dysphoria, treatable with testosterone.

A mutation in the vitamin D receptor causes severe resistance to vitamin D, affecting bone health but not hair growth.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

The equine epididymis mainly uses type 1 5α-reductase, and both finasteride and dutasteride can inhibit its activity.

Siblings with signs of virilization should be tested for non-classical congenital adrenal hyperplasia, which does not affect adult height but may impact fertility and well-being if untreated.

A rare gene variant causes sexual development issues in siblings, needing personalized treatment.

Child with rickets improved with a specific vitamin D therapy, but alopecia did not change.

A boy with a new NR5A1 gene mutation has a sex development disorder without affecting his adrenal glands.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Researchers created a mouse model of a type of rickets that does not cause hair loss.

1α,25-dihydroxyvitamin D3 directly affects cartilage growth and development.

A 36-year-old person with a female appearance but male chromosomes was diagnosed with a rare enzyme deficiency affecting sexual development.

A specific gene variant is linked to severe insulin resistance and hormone imbalance in a teenage girl.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Nocturnal calcium infusions improved a boy's severe rickets without causing hair loss.

Early detection of specific VDR mutations is crucial for effective treatment and better dental outcomes in children with hereditary vitamin D–resistant rickets.

Measuring 17-hydroxyprogesterone in hair can help monitor androgen levels in people with congenital adrenal hyperplasia.

Mutants of CYP154C2 enzyme significantly improved steroid conversion efficiency.

Adolescents with PCOS have higher levels of certain androgens, which are linked to hair growth but don't help diagnose PCOS better than testosterone levels.