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The ovary mainly causes high testosterone in PCO, while the adrenal gland is the main source in IH.

A new genetic change in the keratin 10 gene caused a skin condition called ichthyosis hystrix in a father and his daughter.

Women with congenital adrenal hyperplasia have lower fertility, but with proper treatment, they can conceive successfully.

New SRD5A2 variants may disrupt protein function, aiding diagnosis and treatment of related disorders.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

New A-homo-B, 19-dinor steroids showed strong antiandrogenic activity without affecting the enzyme 5α-reductase or androgen receptor binding.

A mutation in the HOXC13 gene causes hair and nail problems in a Syrian family.

The patient likely has Chrousos syndrome, a rare condition causing insensitivity to glucocorticoids, requiring high-dose dexamethasone treatment.

A boy with Oculodentodigital syndrome had a unique GJA1 gene mutation causing his symptoms.

Ring Chromosome 11 may be linked to conditions like early puberty, excessive hair growth, hair loss, and type 2 diabetes.

A new genetic variant in the LIPH gene causes hair growth issues in a Chinese patient.

Most genetic mutations causing hypohidrotic ectodermal dysplasia in Russian patients are found in the EDA gene.

Most 46XX CAH patients have female identity, but a few identify as male and may need treatment and surgery.

Vitamin D-dependent rickets Type II causes bone problems and hair loss, and doesn't improve with Vitamin D treatment.

A specific metabolite, not a receptor protein, triggers the production of certain kidney enzymes, but this process is disrupted in mice with a mutation causing testicular feminization.

Scientists now better understand the genetics of hypohidrotic ectodermal dysplasia, leading to more accurate diagnoses and potential new treatments.

Genetic variations affect dutasteride treatment response for male pattern hair loss.

Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Older parental age, rural living, and specific genetic mutations increase hypospadias risk in children.

5α-reductase enzymes are crucial in certain disorders, and while treatment advances exist, more research on SRD5A3 is needed.

Vitamin D receptor helps control hair growth genes in skin cells.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

5α-reductase enzyme affects hormone levels, influencing conditions like acne and hair loss.

The antiandrogen 11α-hydroxyprogesterone effectively reduces skin oil and cholesterol when applied to the skin.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

SRD5A1 is crucial in advanced prostate cancer, and blocking both SRD5A1 and SRD5A2 is more effective than targeting SRD5A2 alone.

Steroid 5α-reductase evolved from protists and diversified in eukaryotes, with specific roles in mammals and plants.

Testosterone therapy improved symptoms in a woman with congenital adrenal hyperplasia.