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Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride

45 citations , August 2010 in “Hormone Molecular Biology and Clinical Investigation”

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Animal Models and the Developmental Origins of Polycystic Ovary Syndrome: Increasing Evidence for the Role of Androgens in Programming Reproductive and Metabolic Dysfunction

research Animal Models and the Developmental Origins of Polycystic Ovary Syndrome: Increasing Evidence for the Role of Androgens in Programming Reproductive and Metabolic Dysfunction

44 citations , May 2012 in “Endocrinology”

High levels of androgens during early development may cause PCOS-like symptoms.

research Female Androgenetic Alopecia: An Update on Diagnosis and Management

43 citations , November 2019 in “American Journal of Clinical Dermatology”

FAGA diagnosis uses blood tests and trichoscopy, with treatments like topical minoxidil, oral anti-androgens, and hormone-modulating drugs.

research Cinnamomi Cortex (Cinnamomum verum) Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-reductase

43 citations , August 2016 in “Scientific Reports”

Cinnamomi cortex may help treat prostate enlargement by reducing related proteins.

research Acne in the adult female patient: a practical approach

43 citations , September 2012 in “International Journal of Dermatology”

Hormonal therapies are safe and effective for treating adult women's acne.

research Evidence-based approach to cutaneous hyperandrogenism in women

42 citations , July 2015 in “Journal of The American Academy of Dermatology”

The conclusion is that oral contraceptives and antiandrogens can treat hirsutism and acne in women with cutaneous hyperandrogenism, but more research is needed for effective treatments, especially for hair loss.

research (Neuro-)endocrinology of epithelial hair follicle stem cells

42 citations , March 2008 in “Molecular and Cellular Endocrinology”

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

Tobacco and the Skin: Adverse Effects and Complex Relationships

research Tobacco and the skin

41 citations , June 2010 in “Clinics in Dermatology”

Smoking harms skin health, causing slower wound healing, more wrinkles, and worsening some skin conditions, but may protect against certain others.

research No Evidence that 2D:4D is Related to the Number of CAG Repeats in the Androgen Receptor Gene

40 citations , January 2013 in “Frontiers in Endocrinology”

Finger length ratios are not linked to the number of specific gene repeats affecting testosterone sensitivity.

research Influence of massage and occlusion on the ex vivo skin penetration of rigid liposomes and invasomes

39 citations , November 2013 in “European journal of pharmaceutics and biopharmaceutics”

Massage increases how deep both rigid and flexible liposomes can go into skin, with flexible ones going deeper, and covering the skin (occlusion) helps rigid ones more.

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