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A 22-year-old woman with a rare genetic condition was successfully treated to develop normal female characteristics and regular menstruation.

New steroid compounds effectively inhibit 5α-reductase and may treat hair loss.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

The discovery of 5α-reductase deficiency in guevedoces led to the development of important urologic medications.

Certain genetic changes in the LSS gene cause a rare skin and hair condition.

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

Male cells need DHT to respond to testosterone, while female cells do not.

The R343H mutation in the VDR gene causes vitamin D-resistant rickets with alopecia by impairing specific gene activity.

A new method accurately measures nine specific hormones in human blood.

5α-reductase deficiency can cause ambiguous genitalia and gender dysphoria, treatable with testosterone.

About 2.2% of women with symptoms of high male hormones have a mild form of congenital adrenal hyperplasia, and measuring a specific hormone level can accurately diagnose it.

Girls with PCOS have higher levels of certain androgens, which are linked to excess hair growth, but these androgens don't help diagnose PCOS.

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

Omega-6 fats in certain cells boost male hormone production.

Both enzyme forms can sulfate minoxidil.

Compound 15a was effective in inhibiting 5α-reductase.

Testosterone affects androgen receptors and lipid storage in cells, while DHEA does not convert to testosterone or affect these receptors in the same way.

Women with severe acne, hirsutism, and androgenic alopecia often have higher levels of certain androgens, but the specific pattern can't be predicted just by looking at symptoms.

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

Modified steroidal inhibitors showed promise in treating hormone-dependent cancers.

New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.

Women with hair loss had higher levels of certain hormones, suggesting a link to a condition like PCOS.

Brothers of women with PCOS tend to have higher levels of a hormone called DHEAS, indicating a possible genetic link.

Enzyme replacement therapy may help alleviate symptoms in complex cases like this.

Different skin cells process testosterone differently, and certain drugs can change this process, possibly helping treat acne and hair loss.

Adding a specific gene to skin cells can help treat skin disorders like psoriasis.

A new mutation in the ST14 gene broadens the understanding of ichthyosis-hypotrichosis syndrome.

Some synthesized compounds were more effective than Finasteride in reducing prostate cancer cell growth and androgen levels.