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Ethnicity, Obesity, and the Prevalence of Impaired Glucose Tolerance and Type 2 Diabetes in PCOS: A Systematic Review and Meta-Regression

research Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression

189 citations , March 2018 in “Human Reproduction Update”

Women with PCOS are more likely to have impaired glucose tolerance and type 2 diabetes, especially if they are Asian or obese.

research Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2

175 citations , September 1998 in “British Journal of Dermatology”

Keratin 17 gene mutations cause both steatocystoma multiplex and pachyonychia congenita type 2.

research Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues

140 citations , March 2013 in “The journal of immunology/The Journal of immunology”

Memory regulatory T cells need IL-7, not IL-2, to stay in peripheral tissues.

research Dermatologic Changes Associated With Interleukin 2 Administration

123 citations , September 1987 in “JAMA”

IL-2 treatment causes skin eruptions and other reversible side effects, and may play a role in psoriasis.

research VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK

120 citations , May 2012 in “Experimental Cell Research”

VEGF promotes hair follicle cell growth through the VEGFR-2/ERK pathway.

research Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development.

113 citations , May 2002 in “PubMed”

Overexpressing COX-2 in mice skin reduces skin tumor development.

A Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women

research A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women

100 citations , June 2011 in “Journal of The American Academy of Dermatology”

5% minoxidil foam once daily works as well as 2% minoxidil solution twice daily for female hair growth and is more convenient.

research Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes

79 citations , January 2002 in “Nucleic Acids Research”

BMP-2 activates the Dlx3 gene in mouse skin cells, important for hair and skin development.

Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity

research Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease‐associated psychological morbidity

57 citations , April 2019 in “British journal of dermatology/British journal of dermatology, Supplement”

Alopecia areata involves immune system imbalances that may lead to depression and anxiety.

research New insights into the functions of Cox-2 in skin and esophageal malignancies

54 citations , April 2020 in “Experimental & Molecular Medicine”

Cox-2 significantly contributes to the development and progression of skin and esophageal cancers.

research Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients

48 citations , November 2017 in “Journal of the American Academy of Dermatology”

Tofacitinib 2% ointment helped hair regrow in 3 out of 10 patients with alopecia areata, but caused side effects like scalp irritation and raised cholesterol in some.

research Characterization and expression analysis of KAP7.1, KAP8.2 gene in Liaoning new-breeding cashmere goat hair follicle

48 citations , February 2010 in “Molecular biology reports”

KAP7.1 and KAP8.2 genes are crucial for cashmere quality in goats.

research Clinical dose ranging studies with finasteride, a type 2 5α-reductase inhibitor, in men with male pattern hair loss

46 citations , October 1999 in “Journal of The American Academy of Dermatology”

Finasteride effectively treats male pattern hair loss with a 1 mg daily dose.

research
Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

45 citations , March 2020 in “International Journal of Nanomedicine”

Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.

Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride

45 citations , August 2010 in “Hormone Molecular Biology and Clinical Investigation”

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

research Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments

43 citations , January 2016 in “Oxidative medicine and cellular longevity”

THSG from a Chinese plant helps with aging and related diseases.

research Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia upon Cyclooxygenase-2 Overexpression

41 citations , September 2003 in “Journal of Investigative Dermatology”

Overexpression of COX-2 causes early hair loss in mice, but can be prevented with a COX-2 inhibitor.

research VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro

35 citations , October 2013 in “Journal of Dermatological Science”

VEGF165 influences hair follicle cell growth and movement through VEGFR-2 activation.

research Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2

35 citations , January 2006 in “Cancer Research”

Mice with extra PKCδ resist chemical-induced skin cancer but not UV-induced.

research Radiofrequency treatment induces fibroblast growth factor 2 expression and subsequently promotes neocollagenesis and neoangiogenesis in the skin tissue

32 citations , May 2017 in “Lasers in medical science”

Radiofrequency treatment helps rejuvenate skin by boosting collagen and blood vessel growth.

research Hair corticosterone measurement in mouse models of type 1 and type 2 diabetes mellitus

32 citations , January 2017 in “Physiology & Behavior”

New hair growth corticosterone levels are higher in diabetic mice, indicating long-term stress.

research Finasteride, a Type 2 5α-reductase inhibitor, in the treatment of men with androgenetic alopecia

32 citations , April 1999 in “Expert Opinion on Investigational Drugs”

Finasteride effectively treats male hair loss, improving growth and density.

research Solubility of Minoxidil in Methanol, Ethanol, 1-Propanol, 2-Propanol, 1-Butanol, and Water from (278.15 to 333.15) K

24 citations , April 2011 in “Journal of Chemical & Engineering Data”

Minoxidil dissolves best in methanol and least in water.

research VEGF upregulates VEGF receptor-2 on human outer root sheath cells and stimulates proliferation through ERK pathway

23 citations , June 2012 in “Molecular Biology Reports”

VEGF stimulates hair cell growth and increases growth receptor levels through a specific signaling pathway.

research Adipose stem cells from type 2 diabetic mice exhibit therapeutic potential in wound healing

21 citations , July 2020 in “Stem Cell Research & Therapy”

Fat stem cells from diabetic mice can still help heal wounds.

research The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A

20 citations , August 2020 in “Scientific Reports”

Low-dose bisphenol A increases prostate size in rats by affecting certain enzymes.

Effect of the Polymorphisms of Keratin Associated Protein 8.2 Gene on Fiber Traits in Inner Mongolia Cashmere Goats

research Effect of the Polymorphisms of Keratin Associated Protein 8.2 Gene on Fibre Traits in Inner Mongolia Cashmere Goats

20 citations , May 2007 in “Asian-Australasian Journal of Animal Sciences”

KAP8.2 gene variations affect cashmere quality in goats.

Enhanced Effect of Fibroblast Growth Factor-2-Containing Dalteparin/Protamine Nanoparticles on Hair Growth

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