August 2011 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” 5% minoxidil foam used once daily is as effective as 2% minoxidil solution used twice daily for hair loss in women, but with fewer side effects like itching and dandruff.
845 citations
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February 2001 in “The Journal of Clinical Endocrinology & Metabolism” The enzyme for activating vitamin D is found in many body tissues, not just the kidneys.
January 2021 in “İzmir Dr.Behçet Uz çocuk hastanesi dergisi” Children with Alopecia Areata often have lower vitamin D and B12 levels and higher thyroid activity.
215 citations
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March 2018 in “Archives of Toxicology” Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.
100 citations
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September 1999 in “British Journal of Dermatology” The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.
67 citations
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February 1997 in “Teratology” Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.
46 citations
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October 1999 in “Journal of The American Academy of Dermatology” Finasteride effectively treats male pattern hair loss with a 1 mg daily dose.
45 citations
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August 2010 in “Hormone Molecular Biology and Clinical Investigation” Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.
32 citations
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April 1999 in “Expert Opinion on Investigational Drugs” Finasteride effectively treats male hair loss, improving growth and density.
14 citations
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February 2018 in “Psychoneuroendocrinology” Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.
13 citations
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February 2018 in “Dermatologic Therapy” Finasteride 2.5 mg/day can effectively treat female hair loss.
13 citations
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May 1998 in “The Journal of Clinical Endocrinology & Metabolism” LH and hCG reduce certain protein levels in women's skin.
8 citations
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June 1995 in “Helvetica Chimica Acta” Compound 15a was effective in inhibiting 5α-reductase.
6 citations
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November 2022 in “BMC Urology” Higher levels of miR-1199-5p may reduce the effectiveness of certain prostate treatments.
5 citations
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January 2025 in “Science Advances” 5α-reductase 2 is crucial for stress response in male rats.
2 citations
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January 2025 in “Frontiers in Pharmacology” Purple corn extract may help reduce prostate enlargement and inflammation.
May 2025 in “UNESP Institutional Repository (São Paulo State University)” The 5 mg dose of oral minoxidil is not more effective than the 2.5 mg dose for treating male hair loss.
September 2022 in “Annals of medicine and surgery” Three siblings with a rare genetic condition had abnormal sexual development and chose different gender identities, needing surgery and therapy.
December 2023 in “Biointerface Research in Applied Chemistry” Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.
30 citations
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October 2020 in “Nature Communications” Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.
15 citations
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April 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” A3B5 can reduce skin pigmentation and slow melanoma growth.
4 citations
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July 2020 in “Research Square (Research Square)” The research helps understand how finasteride works and aids drug development.
22 citations
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June 2002 in “Journal of Medicinal Chemistry” Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.
May 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” Jamogenin and other molecules from plants may help treat hair loss.
August 2024 in “Biomedical Journal of Scientific & Technical Research” Jute leaves may help reduce DHT levels, potentially aiding in conditions like hair loss and prostate issues.
January 2023 in “Bioorganičeskaâ himiâ” The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.
70 citations
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November 1984 in “Cell & tissue research/Cell and tissue research” Vitamin D3 affects cell differentiation in specific skin areas.
42 citations
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August 1999 in “The American journal of pathology” Basal cell carcinomas have much higher levels of Vitamin D3 receptors compared to healthy skin.
39 citations
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February 2011 in “The Prostate/The prostate” Some men's prostate tissues have low enzyme levels due to genetic changes, possibly affecting treatment for prostate enlargement.
34 citations
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January 2022 in “Frontiers in Immunology” IL-25 helps heal diabetic wounds by improving blood vessel and skin cell functions.