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Women with severe acne, hirsutism, and androgenic alopecia often have higher levels of certain androgens, but the specific pattern can't be predicted just by looking at symptoms.

Steroid sulfatase inhibitors could help treat hormone-related disorders and cancers.

A 36-year-old person with a female appearance but male chromosomes was diagnosed with a rare enzyme deficiency affecting sexual development.

New nonsteroidal molecules can potentially increase dihydrotestosterone in neurons by blocking certain enzymes, without affecting prostate and seminal vesicle weight.

DDR-II hair follicle cells don't respond to 1, 25-dihydroxyvitamin D3, aiding diagnosis.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Canine hair follicle cells metabolize DHEA and testosterone differently than human cells.

5 alpha-reductase inhibitors, like finasteride, are used to treat conditions like prostate issues and skin disorders.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

New vitamin D3 forms need the vitamin D receptor to reduce fibrosis in human cells.

Different enzymes are active in different parts of developing mouse organs.

A new CDH3 gene mutation was found in a Spanish patient with sparse hair and eye issues.

A mutation in the vitamin D receptor causes severe resistance to vitamin D, affecting bone health but not hair growth.

Vitamin D receptor is crucial for skin wound healing.

Enzyme replacement therapy may help alleviate symptoms in complex cases like this.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Women with nonclassic 21-hydroxylase deficiency can have successful pregnancies through IVF, with certain factors affecting their chances.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Vitamin D receptor is crucial for starting hair growth after birth.

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

A child with a rare type of rickets showed some improvement with high doses of vitamin D, but such conditions often respond poorly to treatment.

Patients with this syndrome can have different responses and worsening resistance to treatment over time.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Alopecia in these mice is caused by defective hair cycle communication due to missing vitamin D receptor function, not vitamin D levels.

Heart-specific steroid metabolism is crucial in cardiac hypertrophy.

The mutated hairless gene causes hair loss by acting as a new type of corepressor affecting thyroid hormone receptors.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.