Search

for
Search:

Did you mean 4-Hydroxycyclophosphamide?

Glossary4-Hydroxycyclophosphamide

active metabolite of cyclophosphamide used in chemotherapy

4-Hydroxycyclophosphamide (4-HC) is an active metabolite of the chemotherapy drug cyclophosphamide. It is formed in the liver and is responsible for the drug's therapeutic effects, as well as some of its side effects. 4-HC works by interfering with the DNA of rapidly dividing cells, which makes it effective in treating certain cancers and autoimmune diseases.

Related Terms

Sort by

Research

30 / 1000+ results

research Peroxisome proliferator-activated receptor-γ signalling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial–mesenchymal transition

19 citations , September 2021 in “British journal of dermatology/British journal of dermatology, Supplement”

Activating PPAR-γ signalling can protect hair follicle stem cells from damage caused by chemotherapy.

Protective Effect of Korean Red Ginseng Against Chemotherapeutic Drug-Induced Premature Catagen Development Assessed With Human Hair Follicle Organ Culture Model

research Protective effect of Korean Red Ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hair follicle organ culture model

19 citations , July 2015 in “Journal of Ginseng Research”

Korean Red Ginseng may protect against hair loss caused by chemotherapy.

research Modulation of Chemotherapy-Induced Human Hair Follicle Damage by 17-β Estradiol and Prednisolone: Potential Stimulators of Normal Hair Regrowth by “Dystrophic Catagen” Promotion?

18 citations , August 2008 in “Journal of Investigative Dermatology”

17-β estradiol and prednisolone may speed up hair regrowth after chemotherapy.

Temporary Cell Cycle Arrest by ALRN-6924: A Novel P53-Targeting Strategy to Protect Human Scalp Hair Follicles Against Cyclophosphamide-Induced Alopecia

research 1409 Temporary cell cycle arrest by ALRN-6924: A novel, p53-targeting strategy to protect human scalp hair follicles against cyclophosphamide-induced alopecia

April 2023 in “Journal of Investigative Dermatology”

ALRN-6924 can protect hair follicles from chemotherapy damage by temporarily stopping cell division.

research Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming?

4 citations , March 2023 in “Current Oncology”

Scalp cooling is the only FDA-approved method to prevent hair loss from chemotherapy, but other treatments like minoxidil and PRP are being tested.

research Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy

32 citations , August 2019 in “Nature Communications”

Chemotherapy causes permanent hair follicle damage by triggering stem cell loss.

research Modeling Chemotherapy-Induced Hair Loss: From Experimental Propositions toward Clinical Reality

6 citations , February 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

A new model using mice with human hair follicles helps better understand hair loss from chemotherapy.

Present Chemotherapy-Induced Alopecia and Future Research

research Present Chemotherapy Induced Alopecia and Research in Future

November 2021 in “Austin therapeutics”

Current treatments for hair loss from chemotherapy are limited, but new methods are being researched.

research Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin

71 citations , May 2007 in “The FASEB journal”

Human hair follicles produce and respond to erythropoietin, helping protect against stress.

Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy

research Complex Changes in the Apoptotic and Cell Differentiation Programs during Initiation of the Hair Follicle Response to Chemotherapy

12 citations , July 2014 in “Journal of Investigative Dermatology”

Chemotherapy causes complex changes in hair follicle cells that can lead to hair loss.

research Chemotherapy-Induced Alopecia

2 citations , January 2012 in “InTech eBooks”

Chemotherapy often causes hair loss, which usually grows back within 3 to 6 months, but there's no effective treatment to prevent it.

research Profiling the Response of Human Hair Follicles to Ultraviolet Radiation

53 citations , January 2009 in “Journal of Investigative Dermatology”

UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.

research Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair

October 2024 in “Annals of Dermatology”

Korean Red Ginseng may help protect hair from damage and promote growth.

research Laminin-511, inducer of hair growth, is down-regulated and its suppressor in hair growth, laminin-332 up-regulated in chemotherapy-induced alopecia

13 citations , April 2010 in “Journal of dermatological science”

Chemotherapy-induced hair loss is partly due to decreased laminin-511 and increased laminin-332.

research Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview

1 citations , December 2023 in “Biomolecules”

Regulating cell death in hair follicles can help prevent hair loss and promote hair growth.

research Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes

186 citations , December 2011 in “Molecules”

Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.

research The Antiandrogenic Action of 4–Androsten–3–one–17β– Carboxylic Acid and Its Methyl Ester on Hamster Flank Organ1

87 citations , April 1973 in “Endocrinology”

The chemicals 17βC and its methyl ester can block the effects of testosterone on hamster skin but not the effects of DHT.

research Involvement of 4‐hydroxy‐2‐nonenal in pollution‐induced skin damage

50 citations , May 2019 in “BioFactors”

Pollution increases a compound in the skin that can lead to faster aging and more inflammation.

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

26 citations , July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

research 13C-NMR study of 4-azasteroids in solution and solid state

25 citations , June 2002 in “Steroids”

4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.

research New approach to 3-oxo-4-aza-5α-androst-1-ene-17β-(--butylcarboxamide)

14 citations , May 2005 in “Steroids”

A new method was developed to make finasteride for treating hair loss.

research 4 Vitamin D resistance

13 citations , April 1994 in “Baillière's clinical endocrinology and metabolism”

Some people have genetic mutations that make them resistant to vitamin D, leading to rickets even with enough vitamin D intake.

research 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice

11 citations , October 2024 in “Cell Death Discovery”

4-aminopyridine helps heal burn wounds faster by reducing inflammation and promoting new blood vessel growth.

4-(Alkylthio)- and 4-(Arylthio)-Benzonitrile Derivatives as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production

research 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production

11 citations , March 2009 in “Bioorganic & Medicinal Chemistry Letters”

Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.

Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production

research Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production

11 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.

Synthesis and Biological Evaluation of 4-(4-(Alkyl- and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-Steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

research Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

8 citations , March 2002 in “Archiv Der Pharmazie”

The compound 4c effectively inhibits the enzyme linked to hair loss.

research 4 Anti-androgens in gynaecological practice

7 citations , September 1988 in “Baillière's clinical obstetrics and gynaecology”

Cyproterone acetate is effective for treating hirsutism and acne in women by blocking androgens in the skin and also works as a contraceptive.

4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

research The hair growth promoting effect of 4-O-methylhonokiol

3 citations , November 2011 in “European Journal of Dermatology”

4-O-methylhonokiol from Magnolia officinalis significantly promotes hair growth.

research Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata

2 citations , December 2022 in “PNAS nexus”

SCD-153 shows promise as an effective topical treatment for alopecia areata.