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A higher genetic risk score increases the chance of getting benign prostatic hyperplasia and affects treatment outcomes in Han Chinese men.

Testosterone works in different ways, including direct interaction with its receptor, conversion to other hormones for specific effects on genitalia, hair, bones, and muscle, and changes in body fat and sexual function when low.

High doses of Lagenaria siceraria fruit powder lower FSH and LH hormone levels in male rats.

Long-term use of certain prostate drugs can worsen erectile dysfunction by changing penile tissue, especially in rats with high blood pressure.

Castration significantly reduces prostate size and BPH symptoms.

Finasteride and dutasteride reduce prostate cancer risk, but finasteride may increase higher-grade cancer risk.

Finasteride reduces prostate size, improves urination, and slows prostate cancer progression.

Provenge extends prostate cancer survival by about 4 months.

Correcting vitamin D and progesterone deficiencies can significantly improve hair loss, acne, and BPH symptoms.

Trienones are more effective at inhibiting the enzyme linked to hair loss than dienones.

Finasteride given to baby rats causes anxiety-like behavior and worsens learning from punishment in adult rats.

Dutasteride reduces DHT more than finasteride, but both drugs improve BPH symptoms similarly.

Finasteride effectively reduces prostate size and symptoms in most BPH patients.

Alligator pepper seed extract improved wound healing in rats.

Infliximab was effective in treating a scalp condition that did not respond to other treatments.

Dutasteride helps reduce heavy drinking, especially for those who drink to cope.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

Finasteride reduces hair growth and is safe for women with excessive hair.

Finasteride doesn't affect hormone levels in normal men.

Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Medications for enlarged prostate can cause sexual side effects like reduced libido, erectile dysfunction, and ejaculatory problems.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

5-alpha reductase inhibitors may have additional effects on cancer, mental health, heart health, and hormone levels beyond treating prostate enlargement.

5-alpha reductase inhibitors help treat prostate issues in aging men, but their role in cancer prevention is debated.

Taking finasteride for benign prostate hyperplasia may increase the risk of osteoporosis, especially at higher doses.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.