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Did you mean Steroid 5 Alpha-Reductase 2?

GlossarySteroid 5 Alpha-Reductase 2

enzyme converting testosterone to potent androgen dihydrotestosterone (DHT)

Steroid 5 Alpha-Reductase 2 (also known as 5α-Reductase Type 2 or SRD5A2) is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen. This enzyme plays a crucial role in the development of male characteristics and is also implicated in conditions like male pattern baldness and benign prostatic hyperplasia.

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research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations , December 2011 in “Advances in Urology”

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

research The biochemical and phenotypic characterization of females homozygous for 5 alpha-reductase-2 deficiency.

54 citations , November 1995 in “The Journal of Clinical Endocrinology & Metabolism”

Females with 5 alpha-reductase-2 deficiency have less body hair, no acne, normal fertility, and delayed menarche.

research 5 alpha-reductase-2 gene mutations in the Dominican Republic.

53 citations , May 1996 in “The Journal of Clinical Endocrinology & Metabolism”

Different mutations in the 5 alpha-reductase-2 gene were found in affected individuals in the Dominican Republic, suggesting no common ancestry.

research 5-Alpha reductase deficiency

38 citations , October 2014 in “Current Opinion in Endocrinology, Diabetes and Obesity”

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

The 5alpha-Reductase Type 1, But Not Type 2, Gene Is Expressed in Anagen Hairs Plucked from the Vertex Area of the Scalp of Hirsute Women and Normal Individuals

research The 5alpha-reductase type 1, but not type 2, gene is expressed in anagen hairs plucked from the vertex area of the scalp of hirsute women and normal individuals

17 citations , October 2003 in “Brazilian Journal of Medical and Biological Research”

The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.

research Homology Modeling of 5-alpha-Reductase 2 Using Available Experimental Data

5 citations , January 2018 in “Interdisciplinary sciences: computational life sciences”

Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.

In Search of Predictive Models for Inhibitors of 5-Alpha Reductase 2 Based on the Integration of Bioactivity and Molecular Descriptors Data

research In Search of Predictive Models for Inhibitors of 5-alpha Reductase 2 Based on the Integration of Bioactivity and Molecular Descriptors Data.

January 2014 in “IWBBIO”

The models can help find better inhibitors for conditions like baldness and prostate disorders.

Purple Corn Extract Improves Benign Prostatic Hyperplasia by Inhibiting 5 Alpha-Reductase Type 2 and Inflammation in Testosterone Propionate-Induced Rats

research Purple corn extract improves benign prostatic hyperplasia by inhibiting 5 alpha-reductase type 2 and inflammation in testosterone propionate-induced rats

2 citations , January 2025 in “Frontiers in Pharmacology”

Purple corn extract may help reduce prostate enlargement and inflammation.

research FRI-02 FROM GIRLS TO BOYS TO OLDER MEN, THE INTERESTING TALE OF THE GUEVEDOCES AND 5-ALPHA REDUCTASE INHIBITORS

March 2016 in “The Journal of Urology”

The discovery of 5α-reductase deficiency in guevedoces led to the development of important urologic medications.

research Contraindicated use of 5-alpha-reductase inhibitors in women

2 citations , August 2016 in “British Journal of Clinical Pharmacology”

The document concludes that women should not use 5-alpha-reductase inhibitors due to the risk of birth defects and limited effectiveness.

Persistent Erectile Dysfunction After Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment

research Persistent Erectile Dysfunction after Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment

17 citations , December 2018 in “The World Journal of Men s Health”

Long-term use of dutasteride can cause permanent erectile dysfunction in rats.

research Impact of Alpha Blockers, 5-alpha Reductase Inhibitors and Combination Therapy on Sexual Function

11 citations , August 2014 in “Current Urology Reports”

Medications for enlarged prostate can cause sexual side effects like reduced libido, erectile dysfunction, and ejaculatory problems.

research An Old Problem with a New Cause-5 Alpha Reductase Inhibitors and Persistent Sexual Dysfunction

9 citations , July 2011 in “The Journal of Sexual Medicine”

Hair loss drugs like finasteride may cause lasting sexual and mood side effects, and more research is needed to understand these risks.

research 5-Alpha Reductase Inhibitors in Prostate Cancer: From Clinical Trials to Clinical Practice

7 citations , January 2013 in “European Urology”

5-Alpha reductase inhibitors may prevent prostate cancer but are not widely used due to concerns about trial relevance and potential risks, and more research is needed to confirm long-term benefits.

5-Alpha-Reductase Inhibitors Reduce Remission Time of COVID-19: Results From a Randomized Double-Blind Placebo-Controlled Interventional Trial in 130 SARS-CoV-2 Positive Men

research 5-Alpha-Reductase Inhibitors Reduce Remission Time of COVID-19: Results From a Randomized Double Blind Placebo Controlled Interventional Trial in 130 SARS-CoV-2 Positive Men

5 citations , November 2020 in “medRxiv (Cold Spring Harbor Laboratory)”

5-Alpha-Reductase inhibitors shorten COVID-19 recovery time in men.

research Pathogenetic justification of the use of 5-alpha reductase inhibitors in the treatment of benign prostatic hyperplasia.

4 citations , September 2022 in “Experimental and Сlinical Urology”

5-alpha reductase inhibitors help with benign prostatic hyperplasia but don't cure it, and more research is needed.

research Risk of Type 2 Diabetes Mellitus in New Users of 5-Alpha Reductase Inhibitors: A Nationwide Historical Cohort Study

January 2026 in “Yonsei Medical Journal”

Finasteride and dutasteride have little effect on Type 2 Diabetes risk.

Effects of Solvent System and Storage Condition on Chemical Stability of 5α-Reductase Inhibitor Compounds in Tectona Grandis Leaf Extracts

research Effects of Solvent System and Storage Condition on Chemical Stability of 5(alpha)-Reductase Inhibitor Compounds in Tectona grandis L.f. Leaf Extracts

February 2024 in “Trends in Sciences”

Store Tectona grandis leaf extracts in slightly acidic, light-protected conditions for best stability.

Reduced Prostate Cancer Risk in Patients with Androgenetic Alopecia Using 5-Alpha Reductase Inhibitors: A TriNetX Real-World Cohort Study

research Reduced Prostate Cancer Risk in Patients with Androgenetic Alopecia Using 5-Alpha Reductase Inhibitors: A TriNetX Real-World Cohort Study

February 2026 in “Mendeley Data”

Using 5-alpha reductase inhibitors may lower prostate cancer risk in people with androgenetic alopecia.

research Reduced Prostate Cancer Risk in Patients with Androgenetic Alopecia Using 5-Alpha Reductase Inhibitors: A TriNetX Real-World Cohort Study

November 2025 in “Mendeley Data”

Using 5-alpha reductase inhibitors may lower prostate cancer risk in people with androgenetic alopecia.

5-Alpha-Reductase Inhibitors: Use in BPH and Androgenic Alopecia

research 5 Alpha Reductase Inhibitors

March 2020 in “StatPearls”

Medicines called 5-alpha-reductase inhibitors, like finasteride and dutasteride, are useful for treating enlarged prostate and male pattern hair loss.

research Structure of human type II 5 alpha-reductase gene.

124 citations , September 1992 in “Endocrinology”

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase

research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase

89 citations , February 1993 in “Journal of Medicinal Chemistry”

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells

research Expression of mRNA for androgen receptor, 5alpha-reductase and 17beta-hydroxysteroid dehydrogenase in human dermal papilla cells

63 citations , November 1999 in “British journal of dermatology/British journal of dermatology, Supplement”

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

research Side Effects of 5‐Alpha Reductase Inhibitors: A Comprehensive Review

35 citations , April 2013 in “Sexual medicine reviews”

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

research Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men.

30 citations , August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.

research Effects of finasteride, a 5 alpha-reductase inhibitor, on circulating androgens and gonadotropin secretion in hirsute women.

22 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces dihydrotestosterone, increases testosterone, and may treat hirsutism in women.

research Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia

19 citations , January 2016 in “Annals of Dermatology”

Dutasteride is safe and effective for treating hair loss, but may decrease libido.

research Effects of the anti-androgen finasteride on 5alpha-reductase activity in human gingival fibroblasts in response to minocycline

15 citations , January 1998 in “Journal of Clinical Periodontology”

Finasteride helps treat hair loss by blocking enzyme activity.