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Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Finasteride raises suicide-linked aggression and stops clozapine's positive effects in schizophrenia animals.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.

Long-term finasteride use doesn't change bone density or metabolism.

Finasteride effectively treats male hair loss, improving growth and density.

Finasteride effectively lowers specific hormone levels, helping monitor treatment progress.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Dutasteride and finasteride do not significantly affect bone density, blood fats, or blood production, but slightly lower PSA levels and minimally impact sexual function in healthy young men.

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

5α-reductase inhibitors like finasteride may not be effective or safe for transgender individuals, and more research is needed.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Finasteride temporarily lowers male rat fertility without affecting libido.

Beetroot extract may help treat hair loss naturally with fewer side effects.

High doses of finasteride cause cell growth and tumors in mice.

Finasteride causes abnormal growth in male mice cells at high doses.

Anti-androgens might help reduce COVID-19 severity in men.

Post-finasteride syndrome is rare but serious and should be taken seriously.

Finasteride effectively treats enlarged prostate and male baldness, improves symptoms of hirsutism in women, but doesn't work for acne, and may delay prostate cancer progression with few side effects.

A gene called Gk5 controls lipid production in the skin and affects hair growth.

Taking oral testosterone with or without dutasteride increases testosterone levels and could be an effective treatment for low testosterone.

5α-reductase inhibitors help shrink the prostate, improve urinary symptoms, and may reduce prostate cancer risk.

Formononetin, found in red clover, may treat hair loss with fewer side effects.

Intralesional therapy for keratoacanthoma is effective and has fewer side effects than systemic treatments.

5α-reductase inhibitors may cause persistent sexual dysfunction and depression, needing more research on long-term effects.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.