31 citations
,
October 1971 in “Steroids” Human beard hair follicles change testosterone into other related hormones, but don't much change androstenedione into testosterone.
29 citations
,
May 1986 in “Journal of Steroid Biochemistry” Androgens don't directly affect hair cell growth or protein production.
28 citations
,
January 2003 in “Urologic oncology” Suppressing certain hormones might help prevent prostate cancer.
25 citations
,
November 1979 in “International Journal of Dermatology” Androgens affect skin conditions like acne and hair loss through specific biochemical pathways.
24 citations
,
September 1996 in “Mycoses” Androgenic steroids can slow down or stop the growth of certain skin fungi.
23 citations
,
July 1979 in “Canadian journal of biochemistry” Spironolactone reduces the number of androgen receptor sites in rat skin by blocking them with its metabolite.
22 citations
,
April 1972 in “Journal of Steroid Biochemistry” Beard hair follicles convert testosterone to 5α-dihydrotestosterone most intensively.
21 citations
,
October 2015 in “Current Drug Targets” Both dutasteride and finasteride improve urinary symptoms, but dutasteride may be better at reducing the risk of prostate surgery and sudden inability to urinate.
21 citations
,
May 2001 in “PubMed” Androgen hormones affect hair growth and oil production, influencing conditions like hair loss and acne.
21 citations
,
August 1994 in “Clinical endocrinology” 5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.
20 citations
,
January 2003 in “Chemical and Pharmaceutical Bulletin” The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.
18 citations
,
November 2021 in “Anais Brasileiros de Dermatologia” COVID-19 can cause various skin issues, like rashes and lesions, which are more common in younger patients and can be linked to more severe complications.
18 citations
,
February 2014 in “PubMed” Androgenetic alopecia is a common hair loss condition caused by testosterone effects on hair follicles, leading to thinner, shorter, and less pigmented hair, diagnosed using scalp dermoscopy and treated with topical minoxidil, antiandrogen agents, and 5-alpha reductase inhibitors.
18 citations
,
December 2010 in “Journal of Trace Elements in Medicine and Biology” Women with AGA have more androstenedione and dihydrotestosterone, less copper and zinc; copper imbalance affects AGA; treatment improves hormones and minerals.
10 citations
,
June 2019 in “International Journal of Cosmetic Science” Some plant-based chemicals may help with hair growth, but more research is needed to confirm their effectiveness.
10 citations
,
March 2019 in “Journal of neuroendocrinology” Testosterone affects stress hormone levels differently in adolescent and adult male rats.
9 citations
,
March 2015 in “Journal of Microbiology and Biotechnology” Ultra-high molecular weight poly-γ-glutamic acid may help promote hair growth.
9 citations
,
April 2007 in “Journal of Andrology” Excessive pre-ejaculation can be treated with certain medications.
8 citations
,
May 2020 in “Arthritis research & therapy” DHT inhibition may increase spinal bone growth in ankylosing spondylitis.
8 citations
,
July 2004 in “The Journal of Clinical Endocrinology & Metabolism” Finasteride is effective for treating BPH but not recommended for prostate cancer prevention.
7 citations
,
January 2022 in “Scientific Reports” Acanthus ebracteatus Vahl. extract and verbascoside may help prevent hair loss and promote hair growth due to their anti-inflammatory properties and ability to protect against cell death.
7 citations
,
January 2004 in “Drugs of today” 5alpha-reductase inhibitors help treat hair loss and prostate issues but may cause sexual side effects.
6 citations
,
February 1996 in “Clinical Pharmacology & Therapeutics” Scale created to measure hair loss in men and women; MK-386 reduces acne; Niaspan treats dyslipidemia; minoxidil increases heart rate.
6 citations
,
January 1994 in “PubMed” The molecular mechanisms controlling hair growth phases are not fully understood yet.
5 citations
,
September 2011 in “Andrologia” Finasteride use may be linked to rare testicular tumor, but more research needed.
5 citations
,
July 1994 in “PubMed” Finasteride, when taken daily, lowers dihydrotestosterone levels but doesn't noticeably affect adrenal steroid production, except by blocking the 5 alpha-reductase enzyme.
4 citations
,
December 2020 in “Giornale italiano di dermatologia e venereologia” Italian guidelines recommend using trichoscopy for diagnosis and treatments like minoxidil for hair loss.
3 citations
,
November 2021 in “Journal of The American Academy of Dermatology” Androgenetic alopecia, a genetic disorder affecting up to 50% of adults, is caused by an excessive response to androgens leading to hair follicle shrinkage. Treatments include FDA-approved drugs, other therapies like low-dose oral minoxidil, and hair transplantation.
3 citations
,
October 2019 in “Dermatologic Therapy” Hair loss in men is mainly caused by hormones and genes, and while current treatments can slow it down, they can't fully stop it.
3 citations
,
September 2016 in “Natural Product Communications” Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.