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Inhibition of 5α-Reductase Impairs Cognitive Performance, Alters Dendritic Morphology, and Increases Tau Phosphorylation in the Hippocampus of Male 3xTg-AD Mice

research Inhibition of 5α Reductase Impairs Cognitive Performance, Alters Dendritic Morphology and Increases Tau Phosphorylation in the Hippocampus of Male 3xTg-AD Mice

13 citations , January 2020 in “Neuroscience”

Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

Rat Steroid 5α-Reductase Kinetic Characteristics: Extreme pH-Dependency of the Type II Isozyme in Prostate and Epididymis Homogenates

research Rat steroid 5α-reductase kinetic characteristics: Extreme pH-dependency of the type II isozyme in prostate and epididymis homogenates

13 citations , August 1995 in “The Journal of Steroid Biochemistry and Molecular Biology”

The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.

research Evaluation of the 5α-reductase inhibitor finasteride on reproduction and gonadal development in medaka, Oryzias latipes

7 citations , April 2015 in “General and Comparative Endocrinology”

Finasteride negatively affects fish reproduction and gonadal development.

research Acute dermal and ocular irritation testing of rice bran supercritical CO2 extract (RB-SCE) and 0.5% RB-SCE essence product

2 citations , March 2015 in “Toxicology and Environmental Health Sciences”

Rice bran extract caused moderate skin irritation but no eye irritation, while a diluted essence was not irritating to skin and only slightly to guinea pigs.

HPLC Profiling and In Silico Studies of Chochurus Olitoris (Jute) Leaf Fractions Against Steroid 5α-Reductase 2 (SRD5α2)

research HPLC Profiling and Insilco studies of Chochurus olitoris (Jute) Leave Fractions against Steroid 5α-Reductase 2 (SRD5α2)

August 2024 in “Biomedical Journal of Scientific & Technical Research”

Jute leaves may help reduce DHT levels, potentially aiding in conditions like hair loss and prostate issues.

Comparative Study of Two Dietary Supplements Inhibiting 5α-Reductase in Female Androgenetic Alopecia

research Estudio comparativo de dos complementos alimenticios inhibidores de la 5a-reductasa en la alopecia androgénica femenina

May 2018 in “Más dermatología”

The higher dose supplement was more effective in treating female hair loss.

research Efficacy of imiquimod 5% cream in the treatment of equine sarcoids: a pilot study

76 citations , July 2006 in “Veterinary Dermatology”

Imiquimod 5% cream reduced equine sarcoids in most cases.

research Pigmented contact dermatitis from topical minoxidil 5%

17 citations , April 2002 in “Contact Dermatitis”

Minoxidil 5% caused skin discoloration in a man using it for hair loss.

Dutasteride, A Novel Dual 5-Alpha Reductase Inhibitor, Reduces Serum DHT to a Greater Extent Versus Finasteride and Achieves Maximal Reduction in a Larger Proportion of Patients

research Dutasteride, a novel dual 5-A reductase inhibitor, reduces serum DHT to a greater extent versus finasteride and achieves finasteride maximal reduction in a larger proportion of patients

12 citations , February 2003 in “European Urology Supplements”

Dutasteride reduces DHT more effectively than finasteride.

research Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5

7 citations , January 2019 in “Pharmaceutical Biology”

Eclipta prostrata helps hair growth and maintains the growth phase by affecting certain growth factors.

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